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Blood, 15 June 2008, Vol. 111, No. 12, pp. 5524-5529. Prepublished online as a Blood First Edition Paper on April 18, 2008; DOI 10.1182/blood-2007-08-109611. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2007-08-109611v1 111/12/5524    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Google Scholar Articles by Schöllkopf, C. Articles by Hjalgrim, H. PubMed PubMed Citation Articles by Schöllkopf, C. Articles by Hjalgrim, H. Related Collections Neoplasia Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL TRIALS AND OBSERVATIONS Borrelia infection and risk of non-Hodgkin lymphoma Claudia Schöllkopf1, Mads Melbye1, Lars Munksgaard2, Karin Ekström Smedby3, Klaus Rostgaard1, Bengt Glimelius4,5, Ellen T. Chang6,7, Göran Roos8, Mads Hansen2, Hans-Olov Adami3,9, and Henrik Hjalgrim1 1 Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark; 2 Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; 3 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; 4 Department of Pathology and Oncology, Karolinska Institutet, Stockholm, Sweden; 5 Department of Oncology, Radiology and Clinical Immunology, Uppsala University, Uppsala, Sweden; 6 Northern California Cancer Center, Fremont; 7 Department of Health Research and Policy, Stanford University School of Medicine, CA; 8 Department of Pathology, Norrlands University Hospital, Umeå, Sweden; and 9 Department of Epidemiology, Harvard School of Public Health, Boston, MA Reports of the presence of Borrelia burgdorferi DNA in malignant lymphomas have raised the hypothesis that infection with B burgdorferi may be causally related to non-Hodgkin lymphoma (NHL) development. We conducted a Danish-Swedish case-control study including 3055 NHL patients and 3187 population controls. History of tick bite or Borrelia infection was ascertained through structured telephone interviews and through enzyme-linked immunosorbent assay serum analyses for antibodies against B burgdorferi in a subset of 1579 patients and 1358 controls. Statistical associations with risk of NHL, including histologic subtypes, were assessed by logistic regression. Overall risk of NHL was not associated with self-reported history of tick bite (odds ratio [OR] = 1.0; 95% confidence interval: 0.9-1.1), Borrelia infection (OR = 1.3 [0.96-1.8]) or the presence of anti-Borrelia antibodies (OR = 1.3 [0.9-2.0]). However, in analyses of NHL subtypes, self-reported history of B burgdorferi infection (OR = 2.5 [1.2-5.1]) and seropositivity for anti-Borrelia antibodies (OR = 3.6 [1.8-7.4]) were both associated with risk of mantle cell lymphoma. Notably, this specific association was also observed in persons who did not recall Borrelia infection yet tested positive for anti-Borrelia antibodies (OR = 4.2 [2.0-8.9]). Our observations suggest a previously unreported association between B burgdorferi infection and risk of mantle cell lymphoma. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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