|
|
Blood, 15 June 2008, Vol. 111, No. 12, pp. 5530-5536.
Prepublished online as a Blood First Edition Paper on April 14, 2008; DOI 10.1182/blood-2008-01-136242.
 Previous Article | Table of Contents | Next Article 
CLINICAL TRIALS AND OBSERVATIONS
Eight-year experience with allogeneic stem cell transplantation for relapsed follicular lymphoma after nonmyeloablative conditioning with fludarabine, cyclophosphamide, and rituximab
Issa F. Khouri1,
Peter McLaughlin2,
Rima M. Saliba1,
Chitra Hosing1,
Martin Korbling1,
Ming S. Lee3,
L. Jeffrey Medeiros3,
Luis Fayad2,
Felipe Samaniego2,
Amin Alousi1,
Paolo Anderlini1,
Daniel Couriel1,
Marcos de Lima1,
Sergio Giralt1,
Sattva S. Neelapu2,
Naoto T. Ueno1,
Barry I. Samuels4,
Fredrick Hagemeister2,
Larry W. Kwak2, and
Richard E. Champlin1
Departments of1 Stem Cell Transplantation and Cellular Therapy,
2 Lymphoma and Myeloma
3 Hematopathology, and
4 Diagnostic Radiology, The University of Texas M. D. Anderson Cancer Center, Houston
Nonmyeloablative stem cell transplantation in patients with follicular lymphoma has been designed to exploit the graft-versus-lymphoma immunity. The long-term effectiveness and toxicity of this strategy, however, is unknown. In this prospective study, we analyzed our 8-year experience. Patients received a conditioning regimen of fludarabine (30 mg/m2 daily for 3 days), cyclophosphamide (750 mg/m2 daily for 3 days), and rituximab (375 mg/m2 for 1 day plus 1000 mg/m2 for 3 days). They were then given an infusion of human leukocyte antigen-matched hematopoietic cells from related (n = 45) or unrelated donors (n = 2). Tacrolimus and methotrexate were used for graft-versus-host disease (GVHD) prophylaxis. Forty-seven patients were included. All patients experienced complete remission, with only 2 relapses. With a median follow-up time of 60 months (range, 19-94), the estimated survival and progression-free survival rates were 85% and 83%, respectively. All 18 patients who were tested and had evidence of JH/bcl-2 fusion transcripts in the bone marrow at study entry experienced continuous molecular remission. The incidence of grade 2-IV acute GVHD was 11%. Only 5 patients were still undergoing immunosuppressive therapy at the time of last follow-up. We believe that the described results are a step forward toward developing a curative strategy for recurrent follicular lymphoma.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
Related Articles in Blood Online:
-
Nonmyeloablative conditioning for relapsed follicular lymphoma
- Koen van Besien and Parameswaran Hari
Blood 2008 112: 2585-2586.
[Full Text]
[PDF]
-
Response: Choice of conditioning for allogeneic transplantation in follicular lymphoma: nonmyeloablative or high-dose chemotherapy?
- Issa F. Khouri
Blood 2008 112: 2586-2587.
[Full Text]
[PDF]
This article has been cited by other articles:
|
|
|
|
 
J. Delgado, D. W. Milligan, and P. Dreger
Allogeneic hematopoietic cell transplantation for chronic lymphocytic leukemia: ready for prime time?
Blood,
September 24, 2009;
114(13):
2581 - 2588.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. J. Moskowitz and C. H. Moskowitz
Controversies in the Treatment of Lymphoma with Autologous Transplantation
Oncologist,
September 1, 2009;
14(9):
921 - 929.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. E. Kohrt, B. B. Turnbull, K. Heydari, J. A. Shizuru, G. G. Laport, D. B. Miklos, L. J. Johnston, S. Arai, W.-K. Weng, R. T. Hoppe, et al.
TLI and ATG conditioning with low risk of graft-versus-host disease retains antitumor reactions after allogeneic hematopoietic cell transplantation from related and unrelated donors
Blood,
July 30, 2009;
114(5):
1099 - 1109.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Foster, D. A. Gabriel, and T. Shea
Role of Hematopoietic Stem Cell Transplant in the Management of Follicular Lymphoma
Oncologist,
July 1, 2009;
14(7):
726 - 738.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. S. Tam, R. Bassett, C. Ledesma, M. Korbling, A. Alousi, C. Hosing, P. Kebraei, R. Harrell, G. Rondon, S. A. Giralt, et al.
Mature results of the M. D. Anderson Cancer Center risk-adapted transplantation strategy in mantle cell lymphoma
Blood,
April 30, 2009;
113(18):
4144 - 4152.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Hagenbeek
Maintenance or Eradication of Residual Disease in Indolent Lymphoma: Where Do We Stand?
J. Clin. Oncol.,
April 1, 2009;
27(10):
1540 - 1542.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Kornacker, J. Stumm, C. Pott, S. Dietrich, S. Sussmilch, M. Hensel, M. Nickelsen, M. Witzens-Harig, M. Kneba, N. Schmitz, et al.
Characteristics of relapse after autologous stem-cell transplantation for follicular lymphoma: a long-term follow-up
Ann. Onc.,
April 1, 2009;
20(4):
722 - 728.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. F. Khouri
Response: Choice of conditioning for allogeneic transplantation in follicular lymphoma: nonmyeloablative or high-dose chemotherapy?
Blood,
September 15, 2008;
112(6):
2586 - 2587.
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. van Besien and P. Hari
Nonmyeloablative conditioning for relapsed follicular lymphoma
Blood,
September 15, 2008;
112(6):
2585 - 2586.
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. G. Till, M. C. Jensen, J. Wang, E. Y. Chen, B. L. Wood, H. A. Greisman, X. Qian, S. E. James, A. Raubitschek, S. J. Forman, et al.
Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells
Blood,
September 15, 2008;
112(6):
2261 - 2271.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
