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Blood, 15 January 2008, Vol. 111, No. 2, pp. 666-671. Prepublished online as a Blood First Edition Paper on October 1, 2007; DOI 10.1182/blood-2007-07-102665. This Article Full Text Full Text (PDF) Supplemental Appendix All Versions of this Article: blood-2007-07-102665v1 111/2/666    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ruggeri, M. Articles by Barbui, T. Search for Related Content PubMed PubMed Citation Articles by Ruggeri, M. Articles by Barbui, T. Related Collections Hemostasis, Thrombosis, and Vascular Biology Neoplasia Free Research Articles Clinical Trials and Observations Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Postsurgery outcomes in patients with polycythemia vera and essential thrombocythemia: a retrospective survey Marco Ruggeri1, Francesco Rodeghiero1, Alberto Tosetto1, Giancarlo Castaman1, Francesca Scognamiglio1, Guido Finazzi2, Federica Delaini2, Caterina Micò2, Alessandro M. Vannucchi3, Elisabetta Antonioli3, Valerio De Stefano4, Tommaso Za4, Luigi Gugliotta5, Alessia Tieghi5, Maria Gabriella Mazzucconi6, Cristina Santoro6, Tiziano Barbui2, for the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) Chronic Myeloproliferative Diseases Working Party 1 Department of Hematology, San Bortolo Hospital, Vicenza; 2 Department of Hematology, Ospedali Riuniti di Bergamo, Bergamo; 3 Department of Hematology, University of Florence, Florence; 4 Institute of Hematology, Catholic University, Rome; 5 Service of Hematology, Santa Maria Nuova Hospital, Reggio Emilia; and 6 Department of Biocellular Technology and Hematology, La Sapienza University, Rome, Italy A multicenter retrospective analysis was performed to estimate the frequency of thrombosis and hemorrhage after surgical procedures in patients with polycythemia vera (PV) and patients with essential thrombocythemia (ET). Data from 105 patients with PV and 150 patients with ET were analyzed, for a total of 311 surgical interventions. An emergency procedure was performed in 25 (8.1%) patients; 194 surgeries were done under general anesthesia, and 21 (23%) of 91 abdominal interventions were done under laparoscopy; 155 (50.1%) were major surgeries. Subcutaneous heparin was administered in 169 (54.3%) of 311 cases and antiplatelet therapy in 48 (15.4%) of 311 case interventions. One hundred eighty-eight (74%) of 255 patients were on cytoreductive therapy before surgery. No events were observed in 259 (83.2%) of 311 procedures during 3 months of follow-up; there were 12 arterial and 12 venous thrombotic events, 23 major and 7 minor hemorrhages, and 5 deaths. Arterial thromboses were more frequent in ET (5.3% vs 1.5%; P = .08), venous events were more frequent in PV (7.7% vs 1.1%; P = .002). There was not a correlation between bleeding episodes and the type of diagnosis, use of antithrombotic prophylaxis, or type of surgery. A high proportion of PV and ET surgeries was complicated by vascular occlusion (7.7%) or by a major hemorrhage (7.3%). Prospective investigations analyzing the optimal prophylaxis in these patients are suggested. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Steel to heal? MPD surgical conundrums Ruben A. Mesa Blood 2008 111: 474. [Full Text] [PDF]

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