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Blood, 15 January 2008, Vol. 111, No. 2, pp. 761-766. Prepublished online as a Blood First Edition Paper on October 29, 2007; DOI 10.1182/blood-2007-08-104877. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2007-08-104877v1 111/2/761    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Haas, J. Articles by Wildemann, B. Search for Related Content PubMed PubMed Citation Articles by Haas, J. Articles by Wildemann, B. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Specific recruitment of regulatory T cells into the CSF in lymphomatous and carcinomatous meningitis Jürgen Haas1, Laila Schopp1, Brigitte Storch-Hagenlocher1, Benedikt Fritzsching2, Christian Jacobi1, Linda Milkova1, Brigitte Fritz1, Alexander Schwarz1, Elisabeth Suri-Payer3, Manfred Hensel4, and Brigitte Wildemann1 1 Division of Molecular Neuroimmunology, Department of Neurology, University of Heidelberg, Heidelberg; 2 Department of Neonatology, Children's Hospital, University of Heidelberg, Heidelberg; 3 Division of Immunogenetics/Tumorimmunology Program, German Cancer Research Center, Heidelberg; and 4 Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany Whereas regulatory T (Treg) cells play an important role in the prevention of autoimmunity, increasing evidence suggests that their down-regulatory properties negatively affect immune responses directed against tumors. Treg cells selectively express chemokine receptors CCR4 and CCR8, and specific migration occurs following the release of various chemokines. Neoplastic meningitis (NM) resulting from leptomeningeal spread of systemic non-Hodgkin lymphoma (NHL) or carcinoma has a poor prognosis. We hypothesized that Treg-cell accumulation within the subarachnoid space as a result of interfering with tumor immunity may be relevant for survival of neoplastic cells. We collected cerebrospinal fluid (CSF) from 101 patients diagnosed with lymphomatous/carcinomatous NM and various inflammatory diseases (IDs) and noninflammatory neurologic disorders (NIDs). CSF Treg- cell counts were determined by flow cytometry, Treg cell–specific chemokines by enzyme-linked immunsorbent assay (ELISA), and Treg-cell trafficking by chemotaxis assay. Both frequencies of Treg-cell and Treg cell–specific chemotactic activities were significantly elevated in CSF samples of patients with NM. Local Treg-cell accumulation occurred without concomitant rise of conventional T (Tconv) cells, coincided with elevated concentrations of Treg cell–attracting chemokines CCL17 and CCL22 and correlated with numbers of atypical CSF cells. We conclude that Treg cells are specifically recruited into the CSF of patients with NM, suggesting that the presence of Treg cells within the subarachnoid space generates a microenvironment that may favor survival and growth of malignant cells. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. W. Mailloux and M. R. I. Young NK-Dependent Increases in CCL22 Secretion Selectively Recruits Regulatory T Cells to the Tumor Microenvironment J. Immunol., March 1, 2009; 182(5): 2753 - 2765. [Abstract] [Full Text] [PDF]

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