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Blood, 1 February 2008, Vol. 111, No. 3, pp. 1004-1012. Prepublished online as a Blood First Edition Paper on October 17, 2007; DOI 10.1182/blood-2007-09-110874. This Article Full Text Full Text (PDF) Supplemental Methods and Figures All Versions of this Article: blood-2007-09-110874v1 111/3/1004    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Bossen, C. Articles by Schneider, P. Search for Related Content PubMed PubMed Citation Articles by Bossen, C. Articles by Schneider, P. Related Collections Immunobiology Chemokines, Cytokines, and Interleukins Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CHEMOKINES, CYTOKINES, AND INTERLEUKINS TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts Claudia Bossen1, Teresa G. Cachero2, Aubry Tardivel1, Karine Ingold1, Laure Willen1, Max Dobles2, Martin L. Scott2, Aris Maquelin1, Elodie Belnoue3, Claire-Anne Siegrist3, Stéphane Chevrier1, Hans Acha-Orbea1, Helen Leung4, Fabienne Mackay4, Jürg Tschopp1, and Pascal Schneider1 1 Department of Biochemistry, University of Lausanne, Epalinges, Switzerland; 2 BiogenIdec, Cambridge, MA; 3 Department of Pathology-Immunology and Pediatrics, University of Geneva, Geneva, Switzerland; and 4 Garvan Institute of Medical Research, Darlinghurst, Australia The cytokine BAFF binds to the receptors TACI, BCMA, and BAFF-R on B cells, whereas APRIL binds to TACI and BCMA only. The signaling properties of soluble trimeric BAFF (BAFF 3-mer) were compared with those of higher-order BAFF oligomers. All forms of BAFF bound BAFF-R and TACI, and elicited BAFF-R–dependent signals in primary B cells. In contrast, signaling through TACI in mature B cells or plasmablasts was only achieved by higher-order BAFF and APRIL oligomers, all of which were also po-tent activators of a multimerization-dependent reporter signaling pathway. These results indicate that, although BAFF-R and TACI can provide B cells with similar signals, only BAFF-R, but not TACI, can respond to soluble BAFF 3-mer, which is the main form of BAFF found in circulation. BAFF 60-mer, an efficient TACI agonist, was also detected in plasma of BAFF transgenic and nontransgenic mice and was more than 100-fold more active than BAFF 3-mer for the activation of multimerization-dependent signals. TACI supported survival of activated B cells and plasmablasts in vitro, providing a rational basis to explain the immunoglobulin deficiency reported in TACI-deficient persons. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Different partners in different places? Michael P. Cancro Blood 2008 111: 975. [Full Text] [PDF] This article has been cited by other articles: J. J. Lee, I. Rauter, L. Garibyan, E. Ozcan, T. Sannikova, S. R. Dillon, A. C. Cruz, R. M. Siegel, R. Bram, H. Jabara, et al. The murine equivalent of the A181E TACI mutation associated with common variable immunodeficiency severely impairs B-cell function Blood, September 10, 2009; 114(11): 2254 - 2262. [Abstract] [Full Text] [PDF] A. Wyzgol, N. Muller, A. Fick, S. Munkel, G. U. Grigoleit, K. Pfizenmaier, and H. Wajant Trimer Stabilization, Oligomerization, and Antibody-Mediated Cell Surface Immobilization Improve the Activity of Soluble Trimers of CD27L, CD40L, 41BBL, and Glucocorticoid-Induced TNF Receptor Ligand J. Immunol., August 1, 2009; 183(3): 1851 - 1861. [Abstract] [Full Text] [PDF] C. Tertilt, J. Joh, A. Krause, P. Chou, K. Schneeweiss, R. G. Crystal, and S. Worgall Expression of B-Cell Activating Factor Enhances Protective Immunity of a Vaccine against Pseudomonas aeruginosa Infect. Immun., July 1, 2009; 77(7): 3044 - 3055. [Abstract] [Full Text] [PDF] U. Salzer, C. Bacchelli, S. Buckridge, Q. Pan-Hammarstrom, S. Jennings, V. Lougaris, A. Bergbreiter, T. Hagena, J. Birmelin, A. Plebani, et al. Relevance of biallelic versus monoallelic TNFRSF13B mutations in distinguishing disease-causing from risk-increasing TNFRSF13B variants in antibody deficiency syndromes Blood, February 26, 2009; 113(9): 1967 - 1976. [Abstract] [Full Text] [PDF] E. Mohr, K. Serre, R. A. Manz, A. F. Cunningham, M. Khan, D. L. Hardie, R. Bird, and I. C. M. MacLennan Dendritic Cells and Monocyte/Macrophages That Create the IL-6/APRIL-Rich Lymph Node Microenvironments Where Plasmablasts Mature J. Immunol., February 15, 2009; 182(4): 2113 - 2123. [Abstract] [Full Text] [PDF]

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