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Blood, 15 February 2008, Vol. 111, No. 4, pp. 1862-1865. Prepublished online as a Blood First Edition Paper on November 20, 2007; DOI 10.1182/blood-2007-09-112953. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2007-09-112953v1 111/4/1862    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Vener, C. Articles by Deliliers, G. L. Search for Related Content PubMed PubMed Citation Articles by Vener, C. Articles by Deliliers, G. L. Related Collections Brief Reports Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL TRIALS AND OBSERVATIONS Brief Report Prognostic implications of the European consensus for grading of bone marrow fibrosis in chronic idiopathic myelofibrosis Claudia Vener1, Nicola Stefano Fracchiolla1, Umberto Gianelli2, Rossella Calori1, Franca Radaelli3, Alessandra Iurlo3, Sabrina Caberlon4, Giancarla Gerli4, Leonardo Boiocchi2, and Giorgio Lambertenghi Deliliers1 1 Ematologia I, Centro Trapianti di Midollo, University of Milan, Fondazione Istituto di ricovero e cura a carattere scientifico (IRCCS) Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan; 2 II Cattedra di Anatomia Patologica, Dipartimento di Medicina, Chirurgia, E Odontoiatria (DMCO), A. O. San Paolo, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan; 3 Divisione di Ematologia, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan; and 4 Unità di Ematologia e Trombosi, Ospedale San Paolo, DMCO, University of Milan, Milan, Italy Various clinical prognostic scoring systems (PSSs) have been suggested as means of selecting high-risk chronic idiopathic myelofibrosis (CIMF) patients at diagnosis. The WHO has recently proposed strict diagnostic criteria for CIMF, and the European consensus for bone marrow fibrosis (BMF) grading recommends 4 classes. It has been suggested that BMF grading may play a prognostic role in CIMF, but it has never been compared with the other PSSs in the same patients. We tested a prognostic model for overall survival (OS) based on the WHO criteria and BMF grading in 113 consecutive patients with chronic myeloproliferative disorders (98 with CIMF and 15 with postpolycythemic myelofibrosis), and compared the findings with those of PSSs. The results showed that our model is significantly associated with different OSs and, unlike the other PSSs, clearly discriminates the OS of intermediate- and high-risk patients. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. Thiele Philadelphia Chromosome-Negative Chronic Myeloproliferative Disease Am J Clin Pathol, August 1, 2009; 132(2): 261 - 280. [Abstract] [Full Text] [PDF] C. Tripodo, A. Di Bernardo, M. P. Ternullo, C. Guarnotta, R. Porcasi, S. Ingrao, U. Gianelli, E. Boveri, E. Iannitto, G. Franco, et al. CD146+ bone marrow osteoprogenitors increase in the advanced stages of primary myelofibrosis Haematologica, January 1, 2009; 94(1): 127 - 130. [Abstract] [Full Text] [PDF]

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