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 Blood, 15 February 2008, Vol. 111, No. 4, pp. 1862-1865.
Prepublished online as a Blood First Edition Paper on November 20, 2007; DOI 10.1182/blood-2007-09-112953.

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CLINICAL TRIALS AND OBSERVATIONS

Brief Report

Prognostic implications of the European consensus for grading of bone marrow fibrosis in chronic idiopathic myelofibrosis

Claudia Vener1, Nicola Stefano Fracchiolla1, Umberto Gianelli2, Rossella Calori1, Franca Radaelli3, Alessandra Iurlo3, Sabrina Caberlon4, Giancarla Gerli4, Leonardo Boiocchi2, and Giorgio Lambertenghi Deliliers1

1 Ematologia I, Centro Trapianti di Midollo, University of Milan, Fondazione Istituto di ricovero e cura a carattere scientifico (IRCCS) Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan; 2 II Cattedra di Anatomia Patologica, Dipartimento di Medicina, Chirurgia, E Odontoiatria (DMCO), A. O. San Paolo, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan; 3 Divisione di Ematologia, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan; and 4 Unità di Ematologia e Trombosi, Ospedale San Paolo, DMCO, University of Milan, Milan, Italy

Various clinical prognostic scoring systems (PSSs) have been suggested as means of selecting high-risk chronic idiopathic myelofibrosis (CIMF) patients at diagnosis. The WHO has recently proposed strict diagnostic criteria for CIMF, and the European consensus for bone marrow fibrosis (BMF) grading recommends 4 classes. It has been suggested that BMF grading may play a prognostic role in CIMF, but it has never been compared with the other PSSs in the same patients. We tested a prognostic model for overall survival (OS) based on the WHO criteria and BMF grading in 113 consecutive patients with chronic myeloproliferative disorders (98 with CIMF and 15 with postpolycythemic myelofibrosis), and compared the findings with those of PSSs. The results showed that our model is significantly associated with different OSs and, unlike the other PSSs, clearly discriminates the OS of intermediate- and high-risk patients.


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