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Blood, 15 February 2008, Vol. 111, No. 4, pp. 2158-2162.
Prepublished online as a Blood First Edition Paper on December 12, 2007; DOI 10.1182/blood-2007-10-117309.
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IMMUNOBIOLOGY
Brief Report
Requirement for CD1d expression by B cells to stimulate NKT cell–enhanced antibody production
Gillian A. Lang1,
T. Scott Devera1, and
Mark L. Lang1
1 Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City
Activation of natural killer-like T (NKT) cells with the CD1d ligand  -galactosylceramide enhances T-dependent humoral immune responses against coadministered T-dependent Ag. At present, there is little information on the mechanisms involved other than a dependence on CD1d expression by antigen-presenting cells and/or development of the NKT subset. We therefore tested the hypothesis that direct presentation of -GC by B cells was required for NKT-enhanced Ab responses against T-dependent Ag. We reconstituted B cell–deficient µMT mice with B cells from C57Bl/6 donors or CD1d–/– donors before immunization with NP-KLH alone or NP-KLH mixed with -GC. We made the surprising observation that B-cell expression of CD1d is absolutely required for the NKT-enhanced Ab response. Our data show that the mechanism by which NKT cells enhance humoral immune responses involves interaction with CD1d-expressing B cells.
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