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Blood, 15 February 2008, Vol. 111, No. 4, pp. 2246-2252. Prepublished online as a Blood First Edition Paper on November 28, 2007; DOI 10.1182/blood-2007-05-092759. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2007-05-092759v1 111/4/2246    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Roos, G. Articles by Stilgenbauer, S. Search for Related Content PubMed PubMed Citation Articles by Roos, G. Articles by Stilgenbauer, S. Related Collections Neoplasia Related Articles in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA Short telomeres are associated with genetic complexity, high-risk genomic aberrations, and short survival in chronic lymphocytic leukemia Göran Roos1, Alexander Kröber2, Pawel Grabowski1, Dirk Kienle2, Andreas Bühler2, Hartmut Döhner2, Richard Rosenquist3, and Stephan Stilgenbauer2 1 Department of Medical Biosciences, Umeå University, Umeå, Sweden; 2 Universität Ulm, Innere Medizin III, Ulm, Germany; and 3 Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden Telomere length is associated with mutation status of the immunoglobulin heavy chain variable (IGHV) gene and clinical course in B-cell chronic lymphocytic leukemia (B-CLL). In a B-CLL cohort of 152 patients, we analyzed telomere length, genomic aberrations, IGHV mutation status, CD38 and ZAP-70 expression to study the prognostic impact and associations among these factors. An inverse correlation existed between telomere length and IGHV homology (P < .001), CD38 (P < .001), and ZAP-70 expression (P = .01). Patients with telomere lengths below median (ie, "short telomeres") and above median (ie, "long telomeres") had similar incidences of genomic aberrations (74% vs 68%), 13q– (57% vs 49%), and +12q (5% vs 12%). In contrast, 13q– as a single aberration was more frequent in patients with long telomeres (51% vs 21%; P = .006), whereas 11q– (27% vs 9%; P = .014), 17p– (17% vs 0%; P < .001), and 2 or more genomic aberrations (39% vs 8%; P < .001) were more frequent in patients with short telomeres. Compared with patients with long telomeres, treatment-free survival (TFS) and overall survival (OS) was significantly shorter (P < .001 and P = .015, respectively) in the group with short telomeres, and telomere length was an independent prognostic indicator for TFS. These observations have biological and prognostic implications in B-CLL. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Articles in Blood Online: Short telomeres in B-CLL: the chicken or the egg? Bernd Jahrsdörfer and George J. Weiner Blood 2008 111: 5756. [Full Text] [PDF] Response: Or both? Göran Roos, Richard Rosenquist, and Stephan Stilgenbauer Blood 2008 111: 5756-5757. [Full Text] [PDF] Do short telomeres shorten CLL survival? Thomas S. Lin Blood 2008 111: 1755. [Full Text] [PDF] This article has been cited by other articles: T. J. Kipps Genomic complexity in chronic lymphocytic leukemia Blood, September 1, 2008; 112(5): 1550 - 1550. [Full Text] [PDF] B. Jahrsdorfer and G. J. Weiner Short telomeres in B-CLL: the chicken or the egg? Blood, June 15, 2008; 111(12): 5756 - 5756. [Full Text] [PDF] G. Roos, R. Rosenquist, and S. Stilgenbauer Response: Or both? Blood, June 15, 2008; 111(12): 5756 - 5757. [Full Text] [PDF]

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