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 Blood, 15 March 2008, Vol. 111, No. 6, pp. 3225-3228.
Prepublished online as a Blood First Edition Paper on January 9, 2008; DOI 10.1182/blood-2007-09-113191.

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NEOPLASIA

Brief Report

The Aiolos transcription factor is up-regulated in chronic lymphocytic leukemia

Marianne Duhamel1, Issam Arrouss1, Hélène Merle-Béral2,3, and Angelita Rebollo1

1 Immunologie Cellulaire et Tissulaire and 2 Service d'Hématologie Biologique, Université Pierre et Marie Curie Paris VI, Paris; and 3 Inserm U543, Hôpital Pitié-Salpêtrière, Paris, France

The Aiolos transcription factor, member of the Ikaros family of zinc finger proteins, plays an important role in the control of mature B lymphocyte differentiation and proliferation, and its function appears to be modulated through alternative splicing. To assess Aiolos isoform role in humans' pathologies, we studied Aiolos variant distribution and expression in mature B lymphoproliferative disorders (chronic lymphocytic leukemia [CLL] and other B-cell lymphomas). We demonstrated that more than 80% of expressed Aiolos in normal as well as in malignant B cells is of the hAio1 type, and we showed for the first time a homogeneous overexpression of the total amounts of Aiolos transcripts in the B cells of CLL patients, independently of ZAP-70 and IgVH mutational status prognosis factors. This up-regulation of Aiolos, confirmed at protein level, seems independent of Aiolos promoter H3K9 acetylation and H3K4 trimethylation.


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