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Blood, 15 November 2008, Vol. 112, No. 10, pp. 3939-3948. This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Mohandas, N. Articles by Gallagher, P. G. Search for Related Content PubMed PubMed Citation Articles by Mohandas, N. Articles by Gallagher, P. G. Related Collections Red Cells Free Research Articles ASH 50th Anniversary Reviews Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  ASH 50TH ANNIVERSARY REVIEWS Red cell membrane: past, present, and future Narla Mohandas1, and Patrick G. Gallagher2 1 Red Cell Physiology Laboratory, New York Blood Center, New York, NY; and 2 Department of Pediatrics, Yale University School of Medicine, New Haven, CT As a result of natural selection driven by severe forms of malaria, 1 in 6 humans in the world, more than 1 billion people, are affected by red cell abnormalities, making them the most common of the inherited disorders. The non-nucleated red cell is unique among human cell type in that the plasma membrane, its only structural component, accounts for all of its diverse antigenic, transport, and mechanical characteristics. Our current concept of the red cell membrane envisions it as a composite structure in which a membrane envelope composed of cholesterol and phospholipids is secured to an elastic network of skeletal proteins via transmembrane proteins. Structural and functional characterization of the many constituents of the red cell membrane, in conjunction with biophysical and physiologic studies, has led to detailed description of the way in which the remarkable mechanical properties and other important characteristics of the red cells arise, and of the manner in which they fail in disease states. Current studies in this very active and exciting field are continuing to produce new and unexpected revelations on the function of the red cell membrane and thus of the cell in health and disease, and shed new light on membrane function in other diverse cell types. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: L. A. Steiner, Y. Maksimova, V. Schulz, C. Wong, D. Raha, M. C. Mahajan, S. M. Weissman, and P. G. Gallagher Chromatin Architecture and Transcription Factor Binding Regulate Expression of Erythrocyte Membrane Protein Genes Mol. Cell. Biol., October 15, 2009; 29(20): 5399 - 5412. [Abstract] [Full Text] [PDF] K. Chen, J. Liu, S. Heck, J. A. Chasis, X. An, and N. Mohandas Resolving the distinct stages in erythroid differentiation based on dynamic changes in membrane protein expression during erythropoiesis PNAS, October 13, 2009; 106(41): 17413 - 17418. [Abstract] [Full Text] [PDF] R. B. Nowak, R. S. Fischer, R. K. Zoltoski, J. R. Kuszak, and V. M. Fowler Tropomodulin1 is required for membrane skeleton organization and hexagonal geometry of fiber cells in the mouse lens J. Cell Biol., September 21, 2009; 186(6): 915 - 928. [Abstract] [Full Text] [PDF]

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