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Blood, 15 November 2008, Vol. 112, No. 10, pp. 4247-4249. Prepublished online as a Blood First Edition Paper on August 18, 2008; DOI 10.1182/blood-2008-05-157974. This Article Full Text Full Text (PDF) Supplemental Table All Versions of this Article: blood-2008-05-157974v1 112/10/4247    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lan, Q. Articles by Rothman, N. Search for Related Content PubMed PubMed Citation Articles by Lan, Q. Articles by Rothman, N. Related Collections Neoplasia Brief Reports Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA Brief Report A prospective study of mitochondrial DNA copy number and risk of non-Hodgkin lymphoma Qing Lan1, Unhee Lim2, Chin-San Liu3, Stephanie J. Weinstein1, Stephen Chanock1, Matthew R. Bonner4, Jarmo Virtamo5, Demetrius Albanes1,*, and Nathaniel Rothman1,* 1 Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, MD; 2 Epidemiology Program, Cancer Research Center of Hawaii, Honolulu; 3 Department of Neurology and Vascular and Genomic Research Center, Changhua Christian Hospital, Changhua, Taiwan; 4 Department of Social and Preventive Medicine, University at Buffalo, State University of New York; and 5 Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, Finland Mitochondrial DNA (mtDNA) copy number is increased in patients with chronic lymphocytic leukemia (CLL), in Burkitt lymphoma and Epstein-Barr virus–transformed lymphoblastoid cell lines, and in T cells activated via the T-cell receptor. We hypothesized that having a higher mtDNA copy number in peripheral white blood cell DNA from healthy subjects would be associated with future risk of non-Hodgkin lymphoma (NHL). We analyzed mtDNA copy number in 104 incident male NHL cases and 104 matched controls within the prospective Alpha-Tocopherol, Beta-Carotene (ATBC) Cancer Prevention cohort. There was a dose-response relationship between tertiles of mtDNA copy number and risk of NHL (odds ratio [OR], 95% confidence interval [CI]: 1.0; 1.4 [0.7-2.8]; and 2.4 [1.0-5.5], respectively; Ptrend = .046). The effect was most pronounced for the CLL/small lymphocytic lymphoma (SLL) subtype (OR: 1.0; 3.2 [0.7-15.7]; 14.1 [1.9-103.2]; Ptrend = .009). These results suggest that mtDNA copy number could be associated with the risk of NHL, particularly CLL/SLL. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: Q. Lan, L. M. Morton, B. Armstrong, P. Hartge, I. Menashe, T. Zheng, M. P. Purdue, J. R. Cerhan, Y. Zhang, A. Grulich, et al. Genetic variation in caspase genes and risk of non-Hodgkin lymphoma: a pooled analysis of 3 population-based case-control studies Blood, July 9, 2009; 114(2): 264 - 267. [Abstract] [Full Text] [PDF]

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