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Blood, 1 December 2008, Vol. 112, No. 12, pp. 4598-4608. Prepublished online as a Blood First Edition Paper on September 11, 2008; DOI 10.1182/blood-2008-06-162651. This Article Full Text Full Text (PDF) Supplemental Table and Figures All Versions of this Article: blood-2008-06-162651v1 112/12/4598    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Malleret, B. Articles by Vaslin, B. Search for Related Content PubMed PubMed Citation Articles by Malleret, B. Articles by Vaslin, B. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Primary infection with simian immunodeficiency virus: plasmacytoid dendritic cell homing to lymph nodes, type I interferon, and immune suppression Benoît Malleret1,2, Benjamin Manéglier3,4,*, Ingrid Karlsson1,2,*, Pierre Lebon5, Michelina Nascimbeni6,7, Leïla Perié6,7, Patricia Brochard1,2, Benoît Delache1,2, Julien Calvo1,2, Thibault Andrieu1,2, Odile Spreux-Varoquaux3,4, Anne Hosmalin6,7, Roger Le Grand1,2, and Bruno Vaslin1,2 1 Commissariat à l'Energie Atomique (CEA), Institute of Emerging Diseases and Innovative Therapies (IMETI), Division of Immuno-Virology (SIV), Fontenay-aux-Roses; 2 Université Paris-Sud, Unité Mixte de Recherche (UMR)–E01, Orsay; 3 Université Versailles St-Quentin, Pharmacologie, Unité Propre de Recherche et de l'Enseignement Supérieur (UPRES), Equipe d'Accueil (EA) 220, Unité de Formation et de Recherche (UFR) Médicale Paris-Ile de France Ouest, Saint-Quentin en Yvelines; 4 Centre Hospitalier de Versailles, Service de Biologie, Unité de Pharmacologie, Le Chesnay; 5 Service de Virologie, Hôpital Cochin-Saint-Vincent-de-Paul, Université Paris Descartes, Paris; 6 Institut Cochin, Université Paris Descartes, Centre National de la Recherche Scientifique (CNRS) UMR 8104, Paris; and 7 Inserm, U567, Paris, France Plasmacytoid dendritic cells (pDCs) are antigen-presenting cells that develop into type-I interferon (IFN-I)–producing cells in response to pathogens. Their role in human immunodeficiency virus (HIV) pathogenesis needs to be understood. We analyzed their dynamics in relation to innate and adaptive immunity very early during the acute phase of simian immunodeficiency virus (SIV) infection in 18 macaques. pDC counts decreased in blood and increased in peripheral lymph nodes, consistent with early recruitment in secondary lymphoid tissues. These changes correlated with the kinetic and intensity of viremia and were associated with a peak of plasma IFN-I. IFN-I and viremia were positively correlated with functional activity of the immune suppression associated enzyme indoleamine-2,3-dioxygenase (IDO) and FoxP3+CD8+ T cells, which both negatively correlated with SIV-specific T-cell proliferation and CD4+ T-cell activation. These data suggest that pDCs and IFN-I play a key role in shaping innate and adaptive immunity toward suppressive pathways during the acute phase of SIV/HIV primary infection. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: G. Stary, I. Klein, S. Kohlhofer, F. Koszik, T. Scherzer, L. Mullauer, H. Quendler, N. Kohrgruber, and G. Stingl Plasmacytoid dendritic cells express TRAIL and induce CD4+ T-cell apoptosis in HIV-1 viremic patients Blood, October 29, 2009; 114(18): 3854 - 3863. [Abstract] [Full Text] [PDF] E. Billerbeck, N. Nakamoto, B. Seigel, H. E. Blum, K.-M. Chang, and R. Thimme Determinants of in vitro expansion of different human virus-specific FoxP3+ regulatory CD8+ T cells in chronic hepatitis C virus infection J. Gen. Virol., July 1, 2009; 90(7): 1692 - 1701. [Abstract] [Full Text] [PDF] M. Nascimbeni, L. Perie, L. Chorro, S. Diocou, L. Kreitmann, S. Louis, L. Garderet, B. Fabiani, A. Berger, J. Schmitz, et al. Plasmacytoid dendritic cells accumulate in spleens from chronically HIV-infected patients but barely participate in interferon-{alpha} expression Blood, June 11, 2009; 113(24): 6112 - 6119. [Abstract] [Full Text] [PDF]

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