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Blood, 15 December 2008, Vol. 112, No. 13, pp. 4895-4904. Prepublished online as a Blood First Edition Paper on September 19, 2008; DOI 10.1182/blood-2007-12-123836. This Article Full Text Full Text (PDF) Supplemental Table and Figures All Versions of this Article: blood-2007-12-123836v1 112/13/4895    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Orelio, C. Articles by Dzierzak, E. Search for Related Content PubMed PubMed Citation Articles by Orelio, C. Articles by Dzierzak, E. Related Collections Hematopoiesis and Stem Cells Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMATOPOIESIS AND STEM CELLS Interleukin-1–mediated hematopoietic cell regulation in the aorta-gonad-mesonephros region of the mouse embryo Claudia Orelio1,*, Esther Haak1,*, Marian Peeters1,*, and Elaine Dzierzak1 1 Department of Cell Biology and Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands Hematopoiesis during development is a dynamic process, with many factors involved in the emergence and regulation of hematopoietic stem cells (HSCs) and progenitor cells. Whereas previous studies have focused on developmental signaling and transcription factors in embryonic hematopoiesis, the role of well-known adult hematopoietic cytokines in the embryonic hematopoietic system has been largely unexplored. The cytokine interleukin-1 (IL-1), best known for its proinflammatory properties, has radioprotective effects on adult bone marrow HSCs, induces HSC mobilization, and increases HSC proliferation and/or differentiation. Here we examine IL-1 and its possible role in regulating hematopoiesis in the midgestation mouse embryo. We show that IL-1, IL-1 receptors (IL-1Rs), and signaling mediators are expressed in the aorta-gonad-mesonephros (AGM) region during the time when HSCs emerge in this site. IL-1 signaling is functional in the AGM, and the IL-1RI is expressed ventrally in the aortic subregion by some hematopoietic, endothelial, and mesenchymal cells. In vivo analyses of IL-1RI–deficient embryos show an increased myeloid differentiation, concomitant with a slight decrease in AGM HSC activity. Our results suggest that IL-1 is an important homeostatic regulator at the earliest time of HSC development, acting to limit the differentiation of some HSCs along the myeloid lineage. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. Orelio, M. Peeters, E. Haak, K. van der Horn, and E. Dzierzak Interleukin-1 regulates hematopoietic progenitor and stem cells in the midgestation mouse fetal liver Haematologica, April 1, 2009; 94(4): 462 - 469. [Abstract] [Full Text] [PDF]

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