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Blood, 15 August 2008, Vol. 112, No. 4, pp. 1317-1324. Prepublished online as a Blood First Edition Paper on June 6, 2008; DOI 10.1182/blood-2008-01-136713. This Article Full Text Full Text (PDF) Supplemental Figures All Versions of this Article: blood-2008-01-136713v1 112/4/1317    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Pitard, V. Articles by Déchanet-Merville, J. Search for Related Content PubMed PubMed Citation Articles by Pitard, V. Articles by Déchanet-Merville, J. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Long-term expansion of effector/memory V2– T cells is a specific blood signature of CMV infection Vincent Pitard1,2, David Roumanes1,2, Xavier Lafarge1,2, Lionel Couzi13, Isabelle Garrigue1,4, Marie-Edith Lafon1,4, Pierre Merville13, Jean-François Moreau1,2,5, and Julie Déchanet-Merville1,2 1 Université Bordeaux 2, Bordeaux; 2 Centre National de la Recherche Scientifique (CNRS) UMR 5164, Bordeaux; 3 Département de Néphrologie et Transplantation Rénale, 4 Laboratoire de Virologie, and 5 Laboratoire d'Immunologie, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France The ability of human T cells to develop immunologic memory is still a matter of debate. We previously demonstrated the involvement of V2– T lymphocytes in the response of immunosuppressed organ recipients to cytomegalovirus (CMV). Here, we demonstrate their ability to mount an adaptive immune response to CMV in immunocompetent subjects. V2– T-cell peripheral blood numbers, repertoire restriction, and cytotoxicity against CMV-infected fibroblasts were markedly increased in CMV-seropositive, compared with CMV-seronegative, healthy persons. Whereas V2– T cells were found as naive cells in CMV– patients, they virtually all exhibited the cytotoxic effector/memory phenotype in CMV+ patients, which is also observed in transplanted patients challenged with CMV. This long-term complete remodeling of the V2– T-cell population by CMV predicts their ability to exhibit an adaptive anti-CMV immune response. Consistent with this, we observed that the secondary response to CMV was associated with a faster T-cell expansion and a better resolution of infection than the primary response. In conclusion, the increased level of effector-memory V2– T cells in the peripheral blood is a specific signature of an adaptive immune response to CMV infection of both immunocompetent and immunosuppressed patients. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: L. Shao, D. Huang, H. Wei, R. C. Wang, C. Y. Chen, L. Shen, W. Zhang, J. Jin, and Z. W. Chen Expansion, Reexpansion, and Recall-Like Expansion of V{gamma}2V{delta}2 T Cells in Smallpox Vaccination and Monkeypox Virus Infection J. Virol., November 15, 2009; 83(22): 11959 - 11965. [Abstract] [Full Text] [PDF] L. T. van der Veken, M. Coccoris, E. Swart, J. H. F. Falkenburg, T. N. Schumacher, and M. H. M. Heemskerk {alpha}{beta} T Cell Receptor Transfer to {gamma}{delta} T Cells Generates Functional Effector Cells without Mixed TCR Dimers In Vivo J. Immunol., January 1, 2009; 182(1): 164 - 170. [Abstract] [Full Text] [PDF]

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