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 Blood, 1 September 2008, Vol. 112, No. 5, pp. 1658-1661.
Prepublished online as a Blood First Edition Paper on June 30, 2008; DOI 10.1182/blood-2008-04-151563.

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CLINICAL TRIALS AND OBSERVATIONS

Brief Report

CNS Hodgkin lymphoma

Elizabeth R Gerstner1, Lauren E Abrey2, David Schiff3, Andrés J. M Ferreri4, Andrew Lister5, Silvia Montoto5, Richard Tsang6, Eckhard Thiel7, Francesc Graus8, Dirk Behringer9, Gerald Illerhaus10, Susan Weaver11, Patrick Wen12, Alfredo Voloschin13, Nancy Lee Harris1, and Tracy T Batchelor1

1 Massachusetts General Hospital, Boston; 2 Memorial Sloan-Kettering Cancer Center, New York, NY; 3 University of Virginia, Charlottesville; 4 San Raffaele Hospital Scientific Institute, Milan, Italy; 5 St Bartholomew's Hospital, London, United Kingdom; 6 Princess Margaret Hospital, Toronto, ON; 7 Charité-Campus Benjamin Franklin, Berlin, Germany; 8 Hospital Clinic, Barcelona, Spain; 9 Augusta-Kranken-Anstalt, Bochum, Germany; 10 University Hospital Freiburg, Freiburg, Germany; 11 Albany Medical Center, NY; 12 Dana-Farber Cancer Institute, Boston, MA; and 13 Medical College of Georgia, Augusta

Central nervous system (CNS) involvement by Hodgkin lymphoma (HL) is rare. As a result, there is limited guidance for clinicians on how to manage these patients. Detailed information was collected on 16 patients, the largest number to date, with meningeal or parenchymal CNS-HL confirmed by histopathology (15) or CSF (1). Eight patients presented with CNS-HL at diagnosis, 2 of whom had isolated CNS disease, while 8 patients developed CNS-HL at relapse. Patients received a range of treatments including surgery or radiation alone, radiation with chemotherapy, or chemotherapy alone. Median overall survival for all 16 patients was 60.9 months from first diagnosis of HL (systemic or CNS) and 43.8 months from diagnosis of CNS-HL. Although a majority of patients have died, long-term survival is possible in patients who achieve a complete response to treatment, particularly those who present with CNS involvement or involvement of the CNS is the sole site of relapsed disease.


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