Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Future Articles
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
 Blood, 15 October 2008, Vol. 112, No. 8, pp. 3048-3051.
Prepublished online as a Blood First Edition Paper on September 5, 2008; DOI 10.1182/blood-2008-02-135715.

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
blood-2008-02-135715v1
blood-2008-02-135715v2
112/8/3048    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Barbi, J.
Right arrow Articles by Satoskar, A. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Barbi, J.
Right arrow Articles by Satoskar, A. R.
Related Collections
Right arrow Immunobiology
Right arrow Brief Reports
Right arrow Chemokines, Cytokines, and Interleukins
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Table of Contents  |  Next Article next article arrow

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

Brief Report

PI3Kgamma (PI3K{gamma}) is essential for efficient induction of CXCR3 on activated T cells

Joseph Barbi1, Hannah E. Cummings1, Bao Lu2, Steve Oghumu1, Thomas Rückle3, Christian Rommel4, William Lafuse5, Caroline C. Whitacre5, and Abhay R. Satoskar1

1 Department of Microbiology, The Ohio State University, Columbus; 2 Ina Sue Perlmutter Laboratory, Children's Hospital, Harvard Medical School, Boston, MA; 3 Merck Serono International SA, Geneva, Switzerland; 4 Intellikine, La Jolla, CA; and 5 Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus

The gamma isoform of PI3Kinase (PI3K{gamma}) controls leukocyte chemotaxis by participating in GPCR signaling, and by regulating cellular polarization. Here we show that PI3K{gamma} is required for efficient induction of CXC chemokine receptor 3 (CXCR3) on T cells upon activation. T cells from PI3K{gamma}–/– mice up-regulated CXCR3 less efficiently than wild-type controls both upon activation in vitro as well as during Leishmania mexicana infection. Inhibition of PI3Kinases using wortmannin and LY294002 or blockade of PI3K{gamma} activity using a selective inhibitor or PI3K{gamma} siRNA suppressed induction of CXCR3 on T cells following activation. Levels of CXCR3 and T-bet mRNA were significantly lower in PI3K{gamma} inhibitor–treated T cells, indicating that PI3K{gamma} may control CXCR3 expression in part through induction of T-bet. These results reveal a novel role for PI3K{gamma} in the induction of CXCR3 on T cells and suggest that PI3K{gamma} may regulate leukocyte chemotaxis by controlling the expression of chemokine receptors.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 2008 by American Society of Hematology         Online ISSN: 1528-0020