SEARCH:   Advanced

Blood, 15 October 2008, Vol. 112, No. 8, pp. 3057-3064. Prepublished online as a Blood First Edition Paper on August 1, 2008; DOI 10.1182/blood-2008-05-160176. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2008-05-160176v1 112/8/3057    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Li, Y.-X. Articles by Yu, Z.-H. Search for Related Content PubMed PubMed Citation Articles by Li, Y.-X. Articles by Yu, Z.-H. Related Collections Neoplasia Free Research Articles Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL TRIALS AND OBSERVATIONS Clinical features and treatment outcome of nasal-type NK/T-cell lymphoma of Waldeyer ring Ye-Xiong Li1, Hui Fang1, Qing-Feng Liu1, Jiade Lu2, Shu-Nan Qi1, Hua Wang1, Jing Jin1, Wei-Hu Wang1, Yue-Ping Liu1, Yong-Wen Song1, Shu-Lian Wang1, Xin-Fan Liu1, Xiao-Li Feng3, and Zi-Hao Yu1 1 Department of Radiation Oncology, Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, People's Republic of China; 2 Department of Radiation Oncology, National University Hospital of Singapore, Singapore; and 3 Department of Pathology, Cancer Hospital, CAMS and PUMC, Beijing, People's Republic of China The clinical characteristics and prognosis remain unclear for nasal-type NK/T-cell lymphoma of Waldeyer ring (WR-NKTL). The aim of this study is to determine the clinical features and outcome. Ninety-one patients with WR-NKTL were reviewed. According to the Ann Arbor system, 15, 56, 12, and 8 patients had stage I, II, III, and IV. Of patients with stage I and II, 54 received combined chemotherapy and radiotherapy (CMT), 13 received radiotherapy alone, and 4 patients received chemotherapy alone. All 20 patients with stage III/IV received primary chemotherapy. The disease is characterized by predominance in young males, good performance, a propensity for nodal involvement, frequent stage II through IV diseases, low frequency of elevated LDH, low-risk international prognostic index (IPI), high sensitivity to radiotherapy, and intermediate sensitivity to chemotherapy. The 5-year overall survival and progression-free survival for all patients were 65% and 51%, respectively. The age, B symptoms, stage, and IPI were important prognostic factors. CMT tended to improve the survival compared with radiotherapy alone for patients with stage I and II diseases. Both nodal involvement and distant extranodal dissemination were the primary failure patterns. WR-NKTL appears to have distinct clinical characteristics and favorable outcomes. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: Y.-X. Li, Q.-F. Liu, H. Fang, S.-N. Qi, H. Wang, W.-H. Wang, Y.-W. Song, J. Lu, J. Jin, S.-L. Wang, et al. Variable Clinical Presentations of Nasal and Waldeyer Ring Natural Killer/T-Cell Lymphoma Clin. Cancer Res., April 15, 2009; 15(8): 2905 - 2912. [Abstract] [Full Text] [PDF]

	Copyright © 2008 by American Society of Hematology         Online ISSN: 1528-0020