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Blood, 1 January 2009, Vol. 113, No. 1, pp. 127-136. Prepublished online as a Blood First Edition Paper on October 1, 2008; DOI 10.1182/blood-2008-04-153031. This Article Full Text Full Text (PDF) Supplemental Tables and Figure All Versions of this Article: blood-2008-04-153031v1 113/1/127    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by van Doorn, R. Articles by Tensen, C. P. Search for Related Content PubMed PubMed Citation Articles by van Doorn, R. Articles by Tensen, C. P. Related Collections Genomics Lymphoid Neoplasia Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  LYMPHOID NEOPLASIA Oncogenomic analysis of mycosis fungoides reveals major differences with Sézary syndrome Remco van Doorn1, Marloes S. van Kester1, Remco Dijkman1, Maarten H. Vermeer1, Aat A. Mulder1, Karoly Szuhai2, Jeroen Knijnenburg2, Judith M. Boer3, Rein Willemze1, and Cornelis P. Tensen1 Departments of 1 Dermatology and 2 Molecular Cell Biology, and 3 Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands Mycosis fungoides (MF), the most common cutaneous T-cell lymphoma, is a malignancy of mature, skin-homing T cells. Sézary syndrome (Sz) is often considered to represent a leukemic phase of MF. In this study, the pattern of numerical chromosomal alterations in MF tumor samples was defined using array-based comparative genomic hybridization (CGH); simultaneously, gene expression was analyzed using microarrays. Highly recurrent chromosomal alterations in MF include gain of 7q36, 7q21-7q22 and loss of 5q13 and 9p21. The pattern characteristic of MF differs markedly from chromosomal alterations observed in Sz. Integration of data from array-based CGH and gene-expression analysis yielded several candidate genes with potential relevance in the pathogenesis of MF. We confirmed that the FASTK and SKAP1 genes, residing in loci with recurrent gain, demonstrated increased expression. The RB1 and DLEU1 tumor suppressor genes showed diminished expression associated with loss. In addition, it was found that the presence of chromosomal alterations on 9p21, 8q24, and 1q21-1q22 was associated with poor prognosis in patients with MF. This study provides novel insight into genetic alterations underlying MF. Furthermore, our analysis uncovered genomic differences between MF and Sz, which suggest that the molecular pathogenesis and therefore therapeutic requirements of these cutaneous T-cell lymphomas may be distinct. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: E. Caprini, C. Cristofoletti, D. Arcelli, P. Fadda, M. H. Citterich, F. Sampogna, A. Magrelli, F. Censi, P. Torreri, M. Frontani, et al. Identification of Key Regions and Genes Important in the Pathogenesis of Sezary Syndrome by Combining Genomic and Expression Microarrays Cancer Res., November 1, 2009; 69(21): 8438 - 8446. [Abstract] [Full Text] [PDF]

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