SEARCH:   Advanced

Blood, 19 March 2009, Vol. 113, No. 12, pp. 2765-3775. Prepublished online as a Blood First Edition Paper on December 18, 2008; DOI 10.1182/blood-2008-07-168096. This Article Full Text Full Text (PDF) Supplemental Tables and Figures All Versions of this Article: blood-2008-07-168096v1 113/12/2765    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Chetaille, B. Articles by Xerri, L. Search for Related Content PubMed PubMed Citation Articles by Chetaille, B. Articles by Xerri, L. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  LYMPHOID NEOPLASIA Molecular profiling of classical Hodgkin lymphoma tissues uncovers variations in the tumor microenvironment and correlations with EBV infection and outcome Bruno Chetaille1,*, François Bertucci1,*, Pascal Finetti1, Benjamin Esterni1, Aspasia Stamatoullas2,3, Jean Michel Picquenot2,3, Marie Christine Copin3,4, Frank Morschhauser3,4, Olivier Casasnovas3,5, Tony Petrella3,5, Thierry Molina3,6, Anne Vekhoff3,6, Pierre Feugier3,7, Reda Bouabdallah1,3, Daniel Birnbaum1,, Daniel Olive1,, and Luc Xerri1,3 1 Departments of Bio-Pathology, Molecular Oncology, Hematology, and Tumor Immunology, Institut Paoli-Calmettes and Université de la Méditerranée, Marseille; 2 Groupe d'Etude des Lymphoproliférations, Centre Henri-Becquerel, Inserm U918, Rouen; 3 Groupe d'Etude des Lymphomes de l'Adulte (GELA), Paris; 4 Department of Pathology and Hematology, Centre Hospitalier and Université de Lille II, Lille; 5 Department of Pathology and Hematology, Centre Hospitalier, Dijon; 6 Department of Pathology and Hematology, Hôtel-Dieu, Paris; and 7 Department of Hematology, Centre Hospitalier, Nancy, France The outcome of classical Hodgkin lymphoma (cHL) patients may be related to the tumor microenvironment, which in turn may be influenced by Epstein-Barr virus (EBV) infection. To characterize the cHL microenvironment, a set of 63 cHL tissue samples was profiled using DNA microarrays. Their gene expression profile differed from that of histiocyte T cell–rich B-cell lymphoma (H/TCRBCL) samples that were used as controls, mainly due to high expression of PDCD1/PD-1 in H/TCRBCL. EBV+ cHL tissues could be distinguished from EBV– samples by a gene signature characteristic of Th1 and antiviral responses. Samples from cHL patients with favorable outcome overexpressed genes specific for B cells and genes involved in apoptotic pathways. An independent set of 146 cHL samples was analyzed using immunohistochemistry. It showed a significant adverse value in case of high percentage of either TIA-1+-reactive cells or topoisomerase-2+ tumor cells, whereas high numbers of BCL11A+, FOXP3+, or CD20+ reactive cells had a favorable influence. Our results suggest an antitumoral role for B cells in the cHL microenvironment and a stronger stromal influence of the PD1 pathway in H/TCRBCL than cHL. The observation of Th1/ antiviral response in EBV+ cHL tissues provides a basis for novel treatment strategies. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. D. Gascoyne Stem cells in Hodgkin lymphoma? Blood, June 4, 2009; 113(23): 5694 - 5694. [Full Text] [PDF]

	Copyright © 2009 by American Society of Hematology         Online ISSN: 1528-0020