Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Future Articles
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
 Blood, 2 April 2009, Vol. 113, No. 14, pp. 3139-3146.
Prepublished online as a Blood First Edition Paper on January 26, 2009; DOI 10.1182/blood-2008-12-172825.

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
blood-2008-12-172825v1
113/14/3139    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hagemann, T.
Right arrow Articles by Lewis, C. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hagemann, T.
Right arrow Articles by Lewis, C. E.
Related Collections
Right arrow Immunobiology
Right arrow Phagocytes, Granulocytes, and Myelopoiesis
Right arrow Review Articles
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Table of Contents  |  Next Article next article arrow

REVIEW ARTICLE

Regulation of macrophage function in tumors: the multifaceted role of NF-{kappa}B

Thorsten Hagemann1,*, Subhra K. Biswas2,*, Toby Lawrence1,*, Antonio Sica3,*, and Claire E. Lewis4,*

1 Centre for Cancer and Inflammation, Institute of Cancer, Barts and the London School of Medicine and Dentistry, London, United Kingdom; 2 Laboratory of Human Innate Immunity, Singapore Immunology Network, Biomedical Sciences Institutes, Agency for Science, Technology & Research, Singapore; 3 Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, and DiSCAFF, University of Piemonte Orientale A Avogadro, Novara, Italy; and 4 Academic Unit of Pathology, University of Sheffield Medical School, Sheffield, United Kingdom

The pivotal role of tumor-associated macrophages (TAMs) in tumor progression is now well established. TAMs have been shown to influence multiple steps in tumor development including the growth, survival, invasion, and metastasis of tumor cells as well as angiogenesis and lymphangiogenesis in tumors. The molecular circuits that polarize TAMs toward such a protumoral phenotype are now the focus of intense investigation. The transcription factor, nuclear factor–{kappa}B (NF-{kappa}B), is a master regulator of many cellular processes and been shown to regulate various pathways that impact on the function of TAMs. Much evidence for this has come from the use of elegant transgenic murine tumor models in which modification of single components of the NF-{kappa}B signaling pathway has been shown to regulate the pro-tumor repertoire of TAMs. Here, we outline this evidence and attempt to reconcile the various views that have emerged recently over the exact role of NF-{kappa}B in this phenomenon.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 JEMHome page
I. Helfrich, I. Scheffrahn, S. Bartling, J. Weis, V. von Felbert, M. Middleton, M. Kato, S. Ergun, and D. Schadendorf
Resistance to antiangiogenic therapy is directed by vascular phenotype, vessel stabilization, and maturation in malignant melanoma
J. Exp. Med., March 15, 2010; 207(3): 491 - 503.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. Mancino and T. Lawrence
Nuclear Factor-{kappa}B and Tumor-Associated Macrophages
Clin. Cancer Res., February 1, 2010; 16(3): 784 - 789.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. G. Ramsay, A. J. Clear, G. Kelly, R. Fatah, J. Matthews, F. MacDougall, T. A. Lister, A. M. Lee, M. Calaminici, and J. G. Gribben
Follicular lymphoma cells induce T-cell immunologic synapse dysfunction that can be repaired with lenalidomide: implications for the tumor microenvironment and immunotherapy
Blood, November 19, 2009; 114(21): 4713 - 4720.
[Abstract] [Full Text] [PDF]

Home page
 Mayo Clin Proc.Home page
S. G. Holtan, D. J. Creedon, P. Haluska, and S. N. Markovic
Cancer and Pregnancy: Parallels in Growth, Invasion, and Immune Modulation and Implications for Cancer Therapeutic Agents
Mayo Clin. Proc., November 1, 2009; 84(11): 985 - 1000.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Porta, M. Rimoldi, G. Raes, L. Brys, P. Ghezzi, D. Di Liberto, F. Dieli, S. Ghisletti, G. Natoli, P. De Baetselier, et al.
Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor {kappa}B
PNAS, September 1, 2009; 106(35): 14978 - 14983.
[Abstract] [Full Text] [PDF]


click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 2009 by American Society of Hematology         Online ISSN: 1528-0020