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Blood, 16 April 2009, Vol. 113, No. 16, pp. 3845-3856. Prepublished online as a Blood First Edition Paper on December 8, 2008; DOI 10.1182/blood-2008-04-153452. This Article Full Text Full Text (PDF) Supplemental Tables, Figures, and Video All Versions of this Article: blood-2008-04-153452v1 113/16/3845    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Samuels, A. L. Articles by Ingley, E. Search for Related Content PubMed PubMed Citation Articles by Samuels, A. L. Articles by Ingley, E. Related Collections Hematopoiesis and Stem Cells Red Cells, Iron, and Erythropoiesis Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  RED CELLS, IRON, AND ERYTHROPOIESIS Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein that influences erythropoietin-induced differentiation Amy L. Samuels1,2, S. Peter Klinken2, and Evan Ingley1,2 1 Cell Signaling Group and 2 Laboratory for Cancer Medicine, Western Australian Institute for Medical Research and Centre for Medical Research, The University of Western Australia, Perth, Australia Erythropoiesis is primarily controlled by erythropoietin (Epo), which stimulates proliferation, differentiation, and survival of erythroid precursors. We have previously shown that the tyrosine kinase Lyn is critical for transducing differentiation signals emanating from the activated Epo receptor. A yeast 2-hybrid screen for downstream effectors of Lyn identified a novel protein, Liar (Lyn-interacting ankyrin repeat), which forms a multiprotein complex with Lyn and HS1 in erythroid cells. Interestingly, 3 of the ankyrin repeats of Liar define a novel SH3 binding region for Lyn and HS1. Liar also contains functional nuclear localization and nuclear export sequences and shuttles rapidly between the nucleus and cytoplasm. Ectopic expression of Liar inhibited the differentiation of normal erythroid progenitors, as well as immortalized erythroid cells. Significantly, Liar affected Epo-activated signaling molecules including Erk2, STAT5, Akt, and Lyn. These results show that Liar is a novel Lyn-interacting molecule that plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Truth or dare: role of Liar in EPO-dependent signaling Dwayne L. Barber Blood 2009 113: 3650-3651. [Full Text] [PDF] This article has been cited by other articles: D. L. Barber Truth or dare: role of Liar in EPO-dependent signaling Blood, April 16, 2009; 113(16): 3650 - 3651. [Full Text] [PDF]

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