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Blood, 21 May 2009, Vol. 113, No. 21, pp. 5090-5093. Prepublished online as a Blood First Edition Paper on March 16, 2009; DOI 10.1182/blood-2008-12-194704. This Article Full Text Full Text (PDF) Supplemental Appendix All Versions of this Article: blood-2008-12-194704v1 113/21/5090    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Renneville, A. Articles by Dombret, H. Search for Related Content PubMed PubMed Citation Articles by Renneville, A. Articles by Dombret, H. Related Collections Myeloid Neoplasia Brief Reports Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL TRIALS AND OBSERVATIONS Brief report The favorable impact of CEBPA mutations in patients with acute myeloid leukemia is only observed in the absence of associated cytogenetic abnormalities and FLT3 internal duplication Aline Renneville1,*, Nicolas Boissel2,*, Nathalie Gachard3, Dina Naguib4, Christian Bastard5, Stéphane de Botton6, Olivier Nibourel1, Cécile Pautas7, Oumedaly Reman4, Xavier Thomas8, Claude Gardin9, Christine Terré10, Sylvie Castaigne10, Claude Preudhomme1, and Hervé Dombret2 1 Department of Hematology, Hôpital Claude Huriez, Lille; 2 Department of Hematology, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP) and EA3518 University Paris 7, Paris; 3 Department of Hematology, Centre Hospitalier Universitaire (CHU) Dupuytren, Limoges; 4 Department of Hematology, CHU, Caen; 5 Department of Hematology, Centre Henri Becquerel, Rouen; 6 Department of Hematology, Institut Gustave Roussy, Villejuif; 7 Department of Hematology, Hôpital Henri Mondor, AP-HP, Créteil; 8 Department of Hematology, Hôpital Edouard Herriot, Lyon; 9 Department of Hematology, Hôpital Avicenne, AP-HP, Bobigny; and 10 Department of Hematology, Hôpital Mignot, Versailles, France Mutations of the CCAAT/enhancer binding protein alpha (CEBPA) gene have been associated with a favorable outcome in patients with acute myeloid leukemia (AML), but mainly in those with a normal karyotype. Here, we analyzed the impact of associated cytogenetic abnormalities or bad-prognosis fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) in 53 patients with CEBPA+ de novo AML treated in the Acute Leukemia French Association trials. We found that only those with a normal karyotype and no FLT3-ITD displayed the expected favorable outcome. In this context, relapse-free, disease-free, and overall survival were significantly longer than in corresponding patients without the CEBPA mutation (P = .035, .016, and .047, respectively). This was not observed in the context of an abnormal karyotype or associated FLT3-ITD. Furthermore, after adjustment on age, trial, and mutation type, these features were independently predictive of shorter overall survival in the subset of patients with CEBPA+ AML (multivariate hazard ratio = 2.7; 95% confidence interval, 1.08-6.7; and 2.9; 95% confidence interval, 1.01-8.2; with P = .034 and .05, for abnormal karyotype and FLT3-ITD, respectively). CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. B. Micol, N. Boissel, A. Renneville, S. Castaigne, C. Gardin, C. Preudhomme, and H. Dombret The role of cytogenetic abnormalities in acute myeloid leukemia with NPM1 mutations and no FLT3 internal tandem duplication Blood, November 12, 2009; 114(20): 4601 - 4602. [Full Text] [PDF] I. H. I. M. Hollink, M. M. van den Heuvel-Eibrink, and C. M. Zwaan CEBPA resembles Roman god Janus Blood, June 25, 2009; 113(26): 6501 - 6502. [Full Text] [PDF]

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