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Blood, 4 June 2009, Vol. 113, No. 23, pp. 5711-5719. Prepublished online as a Blood First Edition Paper on March 18, 2009; DOI 10.1182/blood-2008-10-143560.
HOW I TREAT How we treat cytomegalovirus in hematopoietic cell transplant recipients1 Vaccine and Infectious Disease Institute and Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA; and 2 Department of Hematology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden Cytomegalovirus (CMV) continues to cause major complications after hematopoietic cell transplantation (HCT). Over the past decade, most centers have adopted preemptive antiviral treatment or prophylaxis strategies to prevent CMV disease. Both strategies are effective but also have shortcomings with presently available drugs. Here, we review aspects of CMV treatment and prevention in HCT recipients, including currently used drugs and diagnostics, ways to optimize preemptive therapy strategies with quantitative polymerase chain reaction assays, the use of prophylaxis, management of CMV disease caused by wild-type or drug-resistant strains, and future strategies.
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| Copyright © 2009 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||