Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Future Articles
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
 Blood, 4 June 2009, Vol. 113, No. 23, pp. 5811-5818.
Prepublished online as a Blood First Edition Paper on April 1, 2009; DOI 10.1182/blood-2009-02-203141.

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Figures
Right arrow All Versions of this Article:
blood-2009-02-203141v1
113/23/5811    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Google Scholar
Right arrow Articles by Yao, S.
Right arrow Articles by Chen, L.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yao, S.
Right arrow Articles by Chen, L.
Related Collections
Right arrow Immunobiology
Right arrow Phagocytes, Granulocytes, and Myelopoiesis
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Table of Contents  |  Next Article next article arrow

IMMUNOBIOLOGY

PD-1 on dendritic cells impedes innate immunity against bacterial infection

Sheng Yao1, Shengdian Wang2, Yuwen Zhu1, Liqun Luo1, Gefeng Zhu1, Sarah Flies1, Haiying Xu1, William Ruff1, Megan Broadwater1, In-Hak Choi3, Koji Tamada1, and Lieping Chen1

1 Department of Oncology and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD; 2 Center for Infection and Immunity, Institute of Biophysics, Chinese Academy of Science, Beijing, China; and 3 Department of Microbiology, Inje University College of Medicine, Busan, Republic of Korea

Programmed death one (PD-1) is an inducible molecule belonging to the immunoglobulin superfamily. It is expressed on activated T and B lymphocytes and plays pivotal roles in the negative regulation of adaptive immune responses. We report here an unexpected finding: that PD-1 could also be induced on splenic dendritic cells (DCs) by various inflammatory stimuli. Adoptive transfer of PD-1–deficient DCs demonstrates their superior capacity to wild-type DCs in innate protection of mice against lethal infection by Listeria monocytogenes. Furthermore, PD-1–deficient mice are also more resistant to the infection than wild-type controls, even in the absence of T and B cells, accompanied by elevated production of DC-derived interleukin-12 and tumor necrosis factor-{alpha}. Our results reveal a novel role of PD-1 in the negative regulation of DC function during innate immune response.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 2009 by American Society of Hematology         Online ISSN: 1528-0020