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 Blood, 18 June 2009, Vol. 113, No. 25, pp. 6382-6385.
Prepublished online as a Blood First Edition Paper on February 20, 2009; DOI 10.1182/blood-2009-01-198564.

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IMMUNOBIOLOGY

Brief report

Type I natural killer T cells suppress tumors caused by p53 loss in mice

Jeremy B. Swann1,2, Adam P. Uldrich1, Serani van Dommelen1, Janelle Sharkey1, William K. Murray3, Dale I. Godfrey4, and Mark J. Smyth1,2

1 Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne; 2 Department of Pathology, University of Melbourne, Parkville; 3 Department of Pathology, Peter MacCallum Cancer Centre, East Melbourne, and 4 Department of Microbiology & Immunology, University of Melbourne, Parkville, Australia

CD1d-restricted T cells are considered to play a host protective effect in tumor immunity, yet the evidence for a role of natural killer T (NKT) cells in tumor immune surveillance has been weak and data from several tumor models has suggested that some (type II) CD1d-restricted T cells may also suppress some types of antitumor immune response. To substantiate an important role for CD1d-restricted T cells in host response to cancer, we have evaluated tumor development in p53+/– mice lacking either type I NKT cells (TCR J{alpha}18–/–) or all CD1d-restricted T cells (CD1d–/–). Our findings support a key role for type I NKT cells in suppressing the onset of sarcomas and hematopoietic cancers caused by p53 loss but do not suggest that other CD1d-restricted T cells are critical in regulating the same tumor development.


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Related Article in Blood Online:

NKT cells in p53 deficiency
Madhav V. Dhodapkar and Natalia Neparidze
Blood 2009 113: 6268-6269. [Abstract] [Full Text] [PDF]



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M. V. Dhodapkar and N. Neparidze
NKT cells in p53 deficiency
Blood, June 18, 2009; 113(25): 6268 - 6269.
[Abstract] [Full Text] [PDF]


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