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Blood, 5 February 2009, Vol. 113, No. 6, pp. 1268-1277. Prepublished online as a Blood First Edition Paper on October 22, 2008; DOI 10.1182/blood-2008-07-166553. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2008-07-166553v1 113/6/1268    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Tahvanainen, J. Articles by Lahesmaa, R. Search for Related Content PubMed PubMed Citation Articles by Tahvanainen, J. Articles by Lahesmaa, R. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY PRELI is a mitochondrial regulator of human primary T-helper cell apoptosis, STAT6, and Th2-cell differentiation Johanna Tahvanainen1,2, Teemu Kallonen3, Hanna Lähteenmäki4, Kaisa M. Heiskanen1,5, Jukka Westermarck1,6, Kanury V. S. Rao7, and Riitta Lahesmaa1 1 Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; 2 Drug Discovery Graduate School, University of Turku, Turku, Finland; 3 Department of Bacterial and Inflammatory Diseases, National Public Health Institute, Turku, Finland; 4 Department of Biology, University of Oulu, Oulu, Finland; 5 Department of Biology, University of Turku, Turku, Finland; 6 Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland; and 7 International Centre for Genetic Engineering and Biotechnology, New Delhi, India The identification of novel factors regulating human T helper (Th)–cell differentiation into functionally distinct Th1 and Th2 subsets is important for understanding the mechanisms behind human autoimmune and allergic diseases. We have identified a protein of relevant evolutionary and lymphoid interest (PRELI), a novel protein that induces oxidative stress and a mitochondrial apoptosis pathway in human primary Th cells. We also demonstrated that PRELI inhibits Th2-cell development and down-regulates signal transducer and activator of transcription 6 (STAT6), a key transcription factor driving Th2 differentiation. Our data suggest that calpain, an oxidative stress–induced cysteine protease, is involved in the PRELI-induced down-regulation of STAT6. Moreover, we observed that a strong T-cell receptor (TCR) stimulus induces expression of PRELI and inhibits Th2 development. Our results suggest that PRELI is involved in a mechanism wherein the strength of the TCR stimulus influences the polarization of Th cells. This study identifies PRELI as a novel factor influencing the human primary Th-cell death and differentiation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: Y. Tamura, T. Endo, M. Iijima, and H. Sesaki Ups1p and Ups2p antagonistically regulate cardiolipin metabolism in mitochondria J. Cell Biol., June 15, 2009; 185(6): 1029 - 1045. [Abstract] [Full Text] [PDF]

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