SEARCH:   Advanced

Blood, 12 February 2009, Vol. 113, No. 7, pp. 1501-1503. Prepublished online as a Blood First Edition Paper on December 2, 2008; DOI 10.1182/blood-2008-04-154484. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2008-04-154484v1 113/7/1501    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Solomon, A. Articles by Westermark, P. Search for Related Content PubMed PubMed Citation Articles by Solomon, A. Articles by Westermark, P. Related Collections Immunobiology Lymphoid Neoplasia Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  LYMPHOID NEOPLASIA Brief Report Splenic plasma cells can serve as a source of amyloidogenic light chains Alan Solomon1, Sallie D. Macy1, Craig Wooliver1, Deborah T. Weiss1, and Per Westermark1,2 1 Human Immunology and Cancer Program, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville; and 2 Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden Bone marrow-derived clonal plasma cells, as found in systemic amyloidogenic light chain–associated (AL) amyloidosis, are presumed to be the source of light chains that deposit as fibrils in tissues throughout the body. Paradoxically, people with this disorder, in contrast to multiple myeloma, often have a low percentage of such cells, and it is unknown whether this relatively sparse number can synthesize enough amyloidogenic precursor to form the extensive pathology that occurs. To investigate whether another hematopoietic organ, the spleen, also contains monoclonal light chain–producing plasma cells, we have immunostained such tissue from 26 AL patients with the use of antiplasma cell, antifree and , and anti-VL subgroup-specific monoclonal antibodies (mAbs). In 12 cases, there was statistically significant evidence of a monoclonal population bearing the same or isotype as that within the bone marrow and identical to the amyloid. Our studies have shown that the spleen may be another source of amyloidogenic light chains. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

	Copyright © 2009 by American Society of Hematology         Online ISSN: 1528-0020