SEARCH:   Advanced

Blood, 19 February 2009, Vol. 113, No. 8, pp. 1639-1650. Prepublished online as a Blood First Edition Paper on October 10, 2008; DOI 10.1182/blood-2008-05-159665. This Article Full Text Full Text (PDF) Supplemental Table All Versions of this Article: blood-2008-05-159665v1 113/8/1639    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Iwanaga, M. Articles by Tomonaga, M. Search for Related Content PubMed PubMed Citation Articles by Iwanaga, M. Articles by Tomonaga, M. Related Collections Lymphoid Neoplasia Clinical Trials and Observations Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL TRIALS AND OBSERVATIONS Relationship between monoclonal gammopathy of undetermined significance and radiation exposure in Nagasaki atomic bomb survivors Masako Iwanaga1, Masuko Tagawa2, Kunihiro Tsukasaki1, Tatsuki Matsuo2, Ken-ichi Yokota3, Yasushi Miyazaki1, Takuya Fukushima1, Tomoko Hata1, Yoshitaka Imaizumi1, Daisuke Imanishi1, Jun Taguchi1, Sabro Momita1, Shimeru Kamihira4, and Masao Tomonaga1 1 Department of Hematology and Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; 2 Department of Internal Medicine, Nagasaki Atomic Bomb Casualty Council Health Management Center, Nagasaki; 3 Biostatistics Section, Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; and 4 Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan Radiation exposure is a possible predisposing factor for monoclonal gammopathy of undetermined significance (MGUS), but the association has been uncertain. We investigated the relationship between radiation exposure and MGUS prevalence by using data from the M-protein screening for Nagasaki atomic bomb survivors between 1988 and 2004. Radiation exposure was assessed by exposure distance from the hypocenter and exposure radiation dose. We computed prevalence ratios (PRs) and the 95% confidence intervals (CIs) adjusting for exposure age and sex. A total of 1082 cases of MGUS were identified from 52 525 participants. MGUS prevalence was significantly higher in people exposed at distance within 1.5 km than beyond 3.0 km (PR, 1.4; 95% CI, 1.1-1.9) among those exposed at age 20 years or younger, but it was not found among those exposed at age 20 years or older. MGUS prevalence was also significantly higher in people exposed to more than 0.1 Gy than those exposed to less than 0.01 Gy (PR, 1.7; 95% CI, 1.0-2.8) among those exposed at age 20 years or younger. Thus, people exposed at younger age exhibited a significantly high risk of MGUS when exposed to a high radiation dose. There was no clear association between radiation exposure and the malignant progression of MGUS. Further detailed analysis is needed. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: A role for ionizing radiation in myelomagenesis? Ola Landgren Blood 2009 113: 1616-1617. [Full Text] [PDF] This article has been cited by other articles: O. Landgren A role for ionizing radiation in myelomagenesis? Blood, February 19, 2009; 113(8): 1616 - 1617. [Full Text] [PDF]

	Copyright © 2009 by American Society of Hematology         Online ISSN: 1528-0020