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Blood, 19 February 2009, Vol. 113, No. 8, pp. 1834-1840. Prepublished online as a Blood First Edition Paper on December 5, 2008; DOI 10.1182/blood-2008-07-171702. This Article Full Text Full Text (PDF) Supplemental Figure All Versions of this Article: blood-2008-07-171702v1 113/8/1834    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Janin, A. Articles by Socié, G. Search for Related Content PubMed PubMed Citation Articles by Janin, A. Articles by Socié, G. Related Collections Hematopoiesis and Stem Cells Transplantation Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Donor-derived oral squamous cell carcinoma after allogeneic bone marrow transplantation Anne Janin13, Hideyuki Murata13, Christophe Leboeuf1,2, Jean-Michel Cayuela1,2,4, Eliane Gluckman2,5, Luc Legrès1,2, Allison Desveaux1,2, Mariana Varna1,2, Philippe Ratajczak1,2, Jean Soulier1,2,4, Hugues de Thé2,6,7, Philippe Bertheau13, and Gérard Socié1,2,5 1 Inserm, U728, Paris; 2 Université Paris VII, Institut Universitaire d'Hématologie (IUH), Paris; 3 Service de Pathologie, 4 Laboratoire Central d'Hématologie, 5 Service d'Hématologie Greffe, and 6 Service de Biochimie B, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Paris; and 7 Centre National de la Recherche Scientifique (CNRS), Unité Propre de Recherche (UPR) Unité Mixte de Recherche (UMR) 7151, Université Paris VII, Equipe Labellisée Ligue Nationale Contre le Cancer (LNCC), IUH, Paris, France In animal models, tissue stem cells were proposed to exhibit an unexpected level of plasticity, although issues on cell fusions have lead to some controversies. Only transplantation experiments using genetically distinct recipients and donors can unequivocally show these changes in cell fate. We have analyzed oral squamous cell carcinomas arising in 8 long-term survivors of allogeneic bone marrow transplantation, in whom chronic graft-versus-host disease greatly favors development of squamous cell carcinomas, possibly as a consequence of lichenoid mucosal inflammation. With the use of 2 independent methods, (1) combined immunostaining and fluorescent in situ hybridization (FISH) analysis for X and Y chromosomes sequences in sex-mismatched grafts and (2) comparison of microsatellite typing of laser-microdissected tumor, donor, and recipient cells, in all tumors, we showed that 4 of these 8 epithelial tumors actually arose from the engrafted allogeneic bone marrow. Thus, donor-derived bone marrow cells, whether hematopoietic or mesenchymal, recruited to sites of chronic mucosal inflammation yielded epithelial tumors. Our observations therefore show that marrow cells in humans have a major role in epithelial cancer formation after allogeneic transplantation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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