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Blood, 26 February 2009, Vol. 113, No. 9, pp. 1899-1905. Prepublished online as a Blood First Edition Paper on December 9, 2008; DOI 10.1182/blood-2008-04-153858. This Article Full Text Full Text (PDF) Supplemental Tables All Versions of this Article: blood-2008-04-153858v1 113/9/1899    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Colt, J. S. Articles by Wang, S. S. Search for Related Content PubMed PubMed Citation Articles by Colt, J. S. Articles by Wang, S. S. Related Collections Free Research Articles Lymphoid Neoplasia Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL TRIALS AND OBSERVATIONS Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma Joanne S. Colt1, Nathaniel Rothman1, Richard K. Severson2, Patricia Hartge1, James R. Cerhan3, Nilanjan Chatterjee1, Wendy Cozen4, Lindsay M. Morton1, Anneclaire J. De Roos5, Scott Davis5, Stephen Chanock1,6, and Sophia S. Wang1 1 Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD; 2 Karmanos Cancer Institute and Department of Family Medicine, Wayne State University, Detroit, MI; 3 College of Medicine, Mayo Clinic, Rochester, MN; 4 University of Southern California, Los Angeles; 5 Fred Hutchinson Cancer Research Center and the University of Washington, Seattle; and 6 Core Genotyping Facility, National Cancer Institute, Gaithersburg, MD Organochlorine exposure was linked to non-Hodgkin lymphoma (NHL) risk. To determine whether this relation is modified by immune gene variation, we genotyped 61 polymorphisms in 36 immune genes in 1172 NHL cases and 982 controls from the National Cancer Institute–Surveillance, Epidemiology, and End Results (NCI-SEER) study. We examined 3 exposures with elevated risk in this study: PCB180 (plasma, dust measurements), the toxic equivalency quotient (an integrated functional measure of several organochlorines) in plasma, and -chlordane (dust measurements, self-reported termiticide use). Plasma (100 cases, 100 controls) and dust (682 cases, 513 controls) levels were treated as natural log-transformed continuous variables. Unconditional logistic regression was used to calculate β coefficients and odds ratios, stratified by genotype. Associations between all 3 exposures and NHL risk were limited to the same genotypes for IFNG (C–1615T) TT and IL4 (5'-UTR, Ex1-168C>T) CC. Associations between PCB180 in plasma and dust and NHL risk were limited to the same genotypes for IL16 (3'-UTR, Ex22+871A>G) AA, IL8 (T–251A) TT, and IL10 (A–1082G) AG/GG. This shows that the relation between organochlorine exposure and NHL risk may be modified by particular variants in immune genes and provides one of the first examples of a potential gene-environment interaction for NHL. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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