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Blood, 26 February 2009, Vol. 113, No. 9, pp. 2088-2095. Prepublished online as a Blood First Edition Paper on January 14, 2009; DOI 10.1182/blood-2008-07-168609. This Article Full Text Full Text (PDF) Supplemental Figure All Versions of this Article: blood-2008-07-168609v1 113/9/2088    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Koyama, M. Articles by Teshima, T. Search for Related Content PubMed PubMed Citation Articles by Koyama, M. Articles by Teshima, T. Related Collections Transplantation Related Articles in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Plasmacytoid dendritic cells prime alloreactive T cells to mediate graft-versus-host disease as antigen-presenting cells Motoko Koyama1,2, Daigo Hashimoto3, Kazutoshi Aoyama1,2, Ken-ichi Matsuoka2, Kennosuke Karube4, Hiroaki Niiro1, Mine Harada1, Mitsune Tanimoto2, Koichi Akashi1, and Takanori Teshima3 1 Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka; 2 Biopathological Science, Okayama University Graduate School of Medicine and Dentistry, Okayama; 3 Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka; and 4 Department of Pathology, School of Medicine, Kurume University, Kurume, Japan Dendritic cells (DCs) can be classified into 2 distinct subsets: conventional DCs (cDCs) and plasmacytoid DCs (pDCs). cDCs can prime antigen-specific T-cell immunity, whereas in vivo function of pDCs as antigen-presenting cells remains controversial. We evaluated the contribution of pDCs to allogeneic T-cell responses in vivo in mouse models of graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation by an add-back study of MHC-expressing pDCs into major histocompatibility complex-deficient mice that were resistant to GVHD. Alloantigen expression on pDCs alone was sufficient to prime alloreactive T cells and cause GVHD. An inflammatory environment created by host irradiation has the decisive role in maturing pDCs for T-cell priming but this process does not require Toll-like receptor signaling. Thus, functional outcomes of pDC–T-cell interactions depend on the immunologic context of encounter. To our knowledge, these results are the first to directly demonstrate an in vivo pathogenic role of pDCs as antigen-presenting cells in an antigen-specific T cell–mediated disease in the absence of other DC subsets and to provide important insight into developing strategies for tolerance induction in transplantation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Articles in Blood Online: Response: Recipient plasmacytoid dendritic cells and graft-versus-host disease Takanori Teshima, Masanori Kadowaki, and Motoko Koyama Blood 2009 114: 1280. [Full Text] [PDF] Recipient plasmacytoid DCs are not required to prime allogeneic T-cell responses after BMT Kate A. Markey, Kelli P. A. MacDonald, and Geoffrey R. Hill Blood 2009 113: 6038-6039. [Full Text] [PDF] This article has been cited by other articles: K. A. Markey, K. P. A. MacDonald, and G. R. Hill Recipient plasmacytoid DCs are not required to prime allogeneic T-cell responses after BMT Blood, June 4, 2009; 113(23): 6038 - 6039. [Full Text] [PDF] K. A. Markey, T. Banovic, R. D. Kuns, S. D. Olver, A. L. J. Don, N. C. Raffelt, Y. A. Wilson, L. J. Raggatt, A. R. Pettit, J. S. Bromberg, et al. Conventional dendritic cells are the critical donor APC presenting alloantigen after experimental bone marrow transplantation Blood, May 28, 2009; 113(22): 5644 - 5649. [Abstract] [Full Text] [PDF]

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