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 Blood, 2 July 2009, Vol. 114, No. 1, pp. 2-3.

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InsideBlood

IMMUNOBIOLOGY

Comment on Andersson et al, page 95

"Self"-reflection by KIR

Sarah Cooley, and Jeffrey S. Miller

UNIVERSITY OF MINNESOTA

Abstract

Significant debate exists over the proposed mechanisms by which NK receptor expression coordinates with the acquisition of function and titration of responsiveness, a process called NK-cell education. In this issue of Blood, Andersson and colleagues provide new insights into the mechanisms underlying NK-cell repertoire formation and the modulation of NK-cell function.1


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Related Article in Blood Online:

KIR acquisition probabilities are independent of self-HLA class I ligands and increase with cellular KIR expression
Sandra Andersson, Cyril Fauriat, Jenny-Ann Malmberg, Hans-Gustaf Ljunggren, and Karl-Johan Malmberg
Blood 2009 114: 95-104. [Abstract] [Full Text] [PDF]





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