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 Blood, 2 July 2009, Vol. 114, No. 1, pp. 219-222.
Prepublished online as a Blood First Edition Paper on May 1, 2009; DOI 10.1182/blood-2009-03-209833.

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TRANSPLANTATION

Brief report

Cellular senescence of white blood cells in very long-term survivors after allogeneic hematopoietic stem cell transplantation: the role of chronic graft-versus-host disease and female donor sex

Gabriela M. Baerlocher1,2,*, Alicia Rovó3,*, Astrid Müller2, Sybille Matthey2, Martin Stern3, Jörg Halter3, Dominik Heim3, Johannes Rischewski4, Alois Gratwohl3, and André Tichelli3

1 Department of Hematology, University Hospital, Bern; 2 Department of Clinical Research, University of Bern, Bern; 3 Department of Hematology, University Hospital, Basel; and 4 Department of Oncology, Children's University Hospital Basel, Basel, Switzerland

In this single-center, cross-sectional study, we evaluated 44 very long-term survivors with a median follow-up of 17.5 years (range, 11-26 years) after hematopoietic stem cell transplantation. We assessed the telomere length difference in human leukocyte antigen-identical donor and recipient sibling pairs and searched for its relationship with clinical factors. The telomere length (in kb, mean ± SD) was significantly shorter in all recipient blood cells compared with their donors' blood cells (P < .01): granulocytes (6.5 ± 0.9 vs 7.1 ± 0.9), naive/memory T cells (5.7 ± 1.2 vs 6.6 ± 1.2; 5.2 ± 1.0 vs 5.7 ± 0.9), B cells (7.1 ± 1.1 vs 7.8 ± 1.1), and natural killer/natural killer T cells (4.8 ± 1.0 vs 5.6 ± 1.3). Chronic graft-versus-host disease (P < .04) and a female donor (P < .04) were associated with a greater difference in telomere length between donor and recipient. Critically short telomeres have been described in degenerative diseases and secondary malignancies. If this hypothesis can be confirmed, identification of recipients at risk for cellular senescence could become part of monitoring long-term survivors after hematopoietic stem cell transplantation.


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