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Blood, 2 July 2009, Vol. 114, No. 1, pp. 3.
Mighty mouseTHE OHIO STATE UNIVERSITY Abstract In this issue of Blood, ter Brugge and colleagues describe the results of their efforts to express SV40 T antigen in mature B cells of mice.1 As a consequence of T antigen expression, B cells develop normally but, upon aging, mice show an accumulation of monoclonal CD5+ B cells and have a chronic lymphocytic leukemia-like phenotype.
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