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Blood, 2 July 2009, Vol. 114, No. 1, pp. 3.

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InsideBlood

LYMPHOID NEOPLASIA

Comment on ter Brugge et al, page 119

Mighty mouse

Amy J. Johnson

THE OHIO STATE UNIVERSITY

Abstract

In this issue of Blood, ter Brugge and colleagues describe the results of their efforts to express SV40 T antigen in mature B cells of mice.1 As a consequence of T antigen expression, B cells develop normally but, upon aging, mice show an accumulation of monoclonal CD5+ B cells and have a chronic lymphocytic leukemia-like phenotype.


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Related Article in Blood Online:

A mouse model for chronic lymphocytic leukemia based on expression of the SV40 large T antigen
Petra J. ter Brugge, Van B. T. Ta, Marjolein J. W. de Bruijn, Guido Keijzers, Alex Maas, Dik C. van Gent, and Rudi W. Hendriks
Blood 2009 114: 119-127. [Abstract] [Full Text] [PDF]





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