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 Blood, 2 July 2009, Vol. 114, No. 1, pp. 4.

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InsideBlood

PLATELETS AND THROMBOPOIESIS

Comment on Wen et al, page 153

Megakaryocytes survive without survivin

Katya Ravid

BOSTON UNIVERSITY

Abstract

Survivin has been described as an important regulator of late mitosis and as antiapoptotic in various cells. In this issue of Blood, Wen and colleagues describe a megakaryocyte-specific knockout of survivin, with no influence on megakaryocyte survival, and a stimulating effect on polyploidy.1


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Related Article in Blood Online:

Survivin is not required for the endomitotic cell cycle of megakaryocytes
Qiang Wen, Cindy Leung, Zan Huang, Sara Small, Alagarsamy Lakku Reddi, Jonathan D. Licht, and John D. Crispino
Blood 2009 114: 153-156. [Abstract] [Full Text] [PDF]





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