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Blood, 3 September 2009, Vol. 114, No. 10, pp. 2107-2120. Prepublished online as a Blood First Edition Paper on July 1, 2009; DOI 10.1182/blood-2009-03-211680. This Article Full Text Full Text (PDF) Supplemental Tables and Figures All Versions of this Article: blood-2009-03-211680v1 114/10/2107    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Google Scholar Articles by Migliaccio, A. R. Articles by Fibbe, W. E. PubMed PubMed Citation Articles by Migliaccio, A. R. Articles by Fibbe, W. E. Related Collections Hematopoiesis and Stem Cells Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMATOPOIESIS AND STEM CELLS Gata1 expression driven by the alternative HS2 enhancer in the spleen rescues the hematopoietic failure induced by the hypomorphic Gata1low mutation Anna Rita Migliaccio1,2, Fabrizio Martelli1, Maria Verrucci1, Massimo Sanchez3, Mauro Valeri4, Giovanni Migliaccio3, Alessandro Maria Vannucchi5, Maria Zingariello6, Angela Di Baldassarre6, Barbara Ghinassi2,6, Rosa Alba Rana6, Yvette van Hensbergen7, and Willem E. Fibbe8 1 Department of Hematology/Oncology and Molecular Medicine, Instituto Superiore Sanità, Rome, Italy; 2 Department of Medicine, Mount Sinai School of Medicine and the Myeloproliferative Disease Consortium, New York, NY; Departments of 3 Cell Biology and Neurosciences, and 4 Quality and Security of Animal Experimentation, Instituto Superiore Sanità, Rome, Italy; Departments of 5 Hematology and 6 Biomorphology and Medical Genetics, University G D'Annunzio, Chieti, Azienda Ospedaliera Careggi, Florence, Italy; and 7 Sanquin Blod Foundation and 8 Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands Rigorously defined reconstitution assays developed in recent years have allowed recognition of the delicate relationship that exists between hematopoietic stem cells and their niches. This balance ensures that hematopoiesis occurs in the marrow under steady-state conditions. However, during development, recovery from hematopoietic stress and in myeloproliferative disorders, hematopoiesis occurs in extramedullary sites whose microenvironments are still poorly defined. The hypomorphic Gata1low mutation deletes the regulatory sequences of the gene necessary for its expression in hematopoietic cells generated in the marrow. By analyzing the mechanism that rescues hematopoiesis in mice carrying this mutation, we provide evidence that extramedullary microenvironments sustain maturation of stem cells that would be otherwise incapable of maturing in the marrow. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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