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Blood, 9 July 2009, Vol. 114, No. 2, pp. 444-451. Prepublished online as a Blood First Edition Paper on May 11, 2009; DOI 10.1182/blood-2008-10-182527. This Article Full Text Full Text (PDF) Supplemental Figures All Versions of this Article: blood-2008-10-182527v1 114/2/444    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Google Scholar Articles by Oehmcke, S. Articles by Herwald, H. PubMed PubMed Citation Articles by Oehmcke, S. Articles by Herwald, H. Related Collections Phagocytes, Granulocytes, and Myelopoiesis Thrombosis and Hemostasis Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  THROMBOSIS AND HEMOSTASIS Treatment of invasive streptococcal infection with a peptide derived from human high-molecular weight kininogen Sonja Oehmcke1, Oonagh Shannon1, Maren von Köckritz-Blickwede2, Matthias Mörgelin1, Adam Linder1, Anders I. Olin1, Lars Björck1, and Heiko Herwald1 1 Department of Clinical Sciences, Division of Infection Medicine, Lund University, Lund, Sweden; and 2 Helmholtz Centre for Infection Research, Division of Infection and Immunology, Braunschweig, Germany Sepsis and septic shock remain an important medical problem, emphasizing the need to identify novel therapeutic opportunities. Hypovolemic hypotension, coagulation dysfunction, disturbed microcirculation, and multiorgan failure resulting from vascular leakage are often observed in these severe conditions. In the present study, we find that HKH20, a peptide derived from human high molecular weight kininogen (HK), down-regulates inflammatory reactions caused by Streptococcus pyogenes in a mouse model of sepsis. HK is a component of the pro-inflammatory and pro-coagulant contact system. Activation of the contact system in the bloodstream by S pyogenes leads to massive tissue damage in the lungs of the infected mice, which eventually results in the death of the animals. HKH20 inhibits activation of the contact system and protects mice with invasive S pyogenes infection from lung damage. In combination with clindamycin treatment, the peptide also significantly prolongs the survival of infected mice. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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