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Blood, 13 August 2009, Vol. 114, No. 7, pp. 1355-1365. Prepublished online as a Blood First Edition Paper on June 15, 2009; DOI 10.1182/blood-2008-11-189118. This Article Full Text Full Text (PDF) Supplemental Methods and Figures Additional Supplemental Figures All Versions of this Article: blood-2008-11-189118v1 114/7/1355    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Google Scholar Articles by Saint Fleur, S. Articles by Fujii, H. PubMed PubMed Citation Articles by Saint Fleur, S. Articles by Fujii, H. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Regulation of Fas-mediated immune homeostasis by an activation-induced protein, Cyclon Shella Saint Fleur1, Akemi Hoshino1, Kimie Kondo1, Takeshi Egawa2, and Hodaka Fujii1,3 1 Department of Pathology and 2 Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY; and 3 Combined Program on Microbiology and Immunology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan Activation-induced cell death (AICD) plays an essential role in the contraction of activated T cells after eradication of pathogen. Fas (APO-1/CD95) is one of the key cell surface proteins that mediate AICD in CD4+ and CD8+ T cells. Despite its prime importance in cell death, regulation of Fas expression in T cells is poorly understood. Here we show that Cyclon, a newly identified cytokine-inducible protein, is induced in T cells on T-cell receptor ligation and important for immune homeostasis. Transgenic expression of Cyclon ameliorated autoimmune phenotype in mice lacking subunits of IL-2R. Transgenic expression of Cyclon markedly enhanced AICD through increased expression of Fas whose expression is essential for Cyclon action. Finally, we demonstrated that activated but not resting CD4+ T cells with targeted deletion of a Cyclon allele show reduced AICD and expression of Fas, indicating a critical role of Cyclon in Fas expression in activated T cells. We think that our data provide insight into expression regulation of Fas in T cells. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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