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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by KAPLAN, H. S. Articles by NAGAREDA, C. S. Search for Related Content PubMed PubMed Citation Articles by KAPLAN, H. S. Articles by NAGAREDA, C. S. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1961, Vol. 18, No. 2, pp. 166-175. © 1961 American Society of Hematology, Inc. On the Possibility of Cure of Malignant Lymphoid Tumors. I. Treatment of Autochthonous Lymphoid Tumors in C57BL Mice with Massive Doses of Lymphocytolytic Agents HENRY S. KAPLAN 1 and C. SUSAN NAGAREDA 1 1 Department of Radiology, Stanford University School of Medicine, Stanford, Calif. Strain C57B1 mice in which thymic lymphosarcomas had been induced with total-body X-radiation were treated, at various times in the course of tumor development, with either hydrocortisone or local X-irradiation. Their survival was compared with that of placebo-treated controls. In other sacrificed control groups, the incidence and extent of lymphoma development at the time of treatment was established by microscopic examination. Treatment with single massive doses of hydrocortisone or local thymic X-irradiation at 50 or 100 days after lymphoma induction resulted in permanent cure of half or more of the animals. For a given dose, hydrocortisone was equally effective when given at any time interval up to 100 days after the start of lymphoma induction. However, the therapeutic efficacy of hydrocortisone was a significant function of hormone dose, over the range 0.3 to 3.0 mg. In addition to the cure of many animals, significant prolongation of life was noted in animals dying of lymphomas in all of the treated groups. Submitted on January 3, 1961 Accepted on March 17, 1961 CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. A. KYLE, C. E. MCPARLAND, and W. DAMESHEK Large Doses of Prednisone and Prednisolone in the Treatment of Malignant Lymphoproliferative Disorders Ann Intern Med, November 1, 1962; 57(5): 717 - 731. [Abstract] [PDF]

	Copyright © 1961 by American Society of Hematology         Online ISSN: 1528-0020