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Prepublished online as a Blood First Edition Paper on June 28, 2002; DOI 10.1182/blood-2001-11-0080. This Article Full Text (PDF) All Versions of this Article: 2001-11-0080v1 100/4/1381    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Harari, A. Articles by Pantaleo, G. Search for Related Content PubMed PubMed Citation Articles by Harari, A. Articles by Pantaleo, G. Social Bookmarking                   What's this? Submitted December 20, 2001 Accepted April 8, 2002 Analysis Of HIV-1- And CMV-Specific Memory CD4 T Cell Responses During Primary and Chronic Infection Alexandre Harari, G Paolo Rizzardi, Kim Ellefsen, Donatella Cuiffreda, Patrick Champagne, Pierre-Alexandre Bart, Daniel Kaufmann, Amalio Telenti, Roland Sahli, Giuseppe Tambussi, Laurent Kaiser, Adriano Lazzarin, Luc Perrin, and Giuseppe Pantaleo* Laboratory of AIDS Immunopathogenesis, Divisions of Immunology and Allergy, University of Lausanne, Lausanne, Switzerland Division of Infectious Diseases, Department of Medicine, University of Lausanne, Lausanne, Switzerland Institute of Microbiology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland Division of Infectious Diseases, San Raffaele Institute, Milan, Italy Laboratory of Virology, University of Geneva, Geneva, Switzerland Laboratory of AIDS Immunopathogenesis, Divisions of Immunology and Allergy, University of Lausanne, Lausanne, Switzerland; Division of Infectious Diseases, Department of Medicine, University of Lausanne, Lausanne, Switzerland * Corresponding author; email: giuseppe.pantaleo{at}chuv.hospvd.ch. CD4 T cell-specific memory antiviral responses to HIV-1 and to cytomegalovirus (CMV) were investigated in 16 patients with documented primary HIV-1 infection (4 out of 16 subjects had also primary CMV infection) and compared with those observed in patients with chronic HIV-1 and CMV co-infection. Virus-specific memory CD4 T cells were characterized on the basis of the expression of the chemokine receptor CCR7. HIV-1- and CMV-specific IFN- secreting CD4 T cells were detected in patients with primary and chronic HIV-1 and CMV co-infection and were mostly contained in the cell population lacking expression of CCR7. The magnitude of the primary CMV-specific CD4 T cell response was significantly greater compared to that of chronic CMV infection while there were no differences between primary and chronic HIV-1-specific CD4 T cell responses. A substantial proportion of CD4+CCR7- T cells were infected with HIV-1. 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