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Prepublished online as a Blood First Edition Paper on April 30, 2002; DOI 10.1182/blood-2001-12-0174. This Article Full Text (PDF) All Versions of this Article: 2001-12-0174v1 99/11/4222    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Estey, E. H Articles by Kantarjian, H. M Search for Related Content PubMed PubMed Citation Articles by Estey, E. H Articles by Kantarjian, H. M Social Bookmarking                   What's this? Submitted December 5, 2001 Accepted January 17, 2002 Experience with gemtuzumab oxogamycin (mylotarg) + all-trans retinoic acid in untreated acute promyelocytic leukemia Elihu H Estey*, Francis J Giles, Miloslav Beran, Susan O'Brien, Sherry A Pierce, Stefan H Faderl, Jorge E Cortes, and Hagop M Kantarjian Department of Leukemia, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA * Corresponding author; email: ehestey{at}mdanderson.org. We administered gemtuzumab ozogamycin ("mylotarg", 9 mg/m2 day 1 or 5 ) and all-transretinoic acid (ATRA) to 19 patients with untreated acute promyelocytic leukemia (APL). 3 of the patients also received idarubicin because of a WBC >30,000/µl. In CR, patients were to receive 8 courses of mylotarg (9 mg/m2 every 4-5 weeks) and ATRA; idarubicin was added only for persistent or recurrent PCR positivity. The CR rate was 16/19 (84%). All 12 patients tested to date were PCR negative 2-4 months from CR date; none of the 7 patients evaluated subsequently have reverted to PCR positivity (median follow-up in CR 5 months, up to 14). Mylotarg was well-tolerated. A median of 5 post-CR courses have been given to date. Three patients having currently received 8 and four 7 post-CR courses. Mylotarg appears active in APL, and repeated administration is feasible. ehestey@mdanderson.org CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. Kelaidi, S. Chevret, S. De Botton, E. Raffoux, A. Guerci, X. Thomas, A. Pigneux, T. Lamy, F. Rigal-Huguet, S. Meyer-Monard, et al. Improved Outcome of Acute Promyelocytic Leukemia With High WBC Counts Over the Last 15 Years: The European APL Group Experience J. Clin. Oncol., June 1, 2009; 27(16): 2668 - 2676. [Abstract] [Full Text] [PDF] M. A. Sanz, D. Grimwade, M. S. Tallman, B. Lowenberg, P. Fenaux, E. H. 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