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Prepublished online as a Blood First Edition Paper on May 13, 2002; DOI 10.1182/blood-2001-12-0179. This Article Full Text (PDF) All Versions of this Article: 2001-12-0179v1 100/5/1780    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Engering, A. Articles by van Kooyk, Y. Search for Related Content PubMed PubMed Citation Articles by Engering, A. Articles by van Kooyk, Y. Social Bookmarking                   What's this? Submitted December 6, 2001 Accepted May 1, 2002 Subset of DC-SIGN+ Dendritic Cells in Human Blood Transmits HIV-1 to T Lymphocytes Anneke Engering, Sandra J van Vliet, Teunis B Geijtenbeek, and Yvette van Kooyk* Department of Molecular Cell Biology, VU Medical Center, Amsterdam, The Netherlands * Corresponding author; email: y.van.kooyk.cell{at}med.vu.nl. The dendritic cell (DC)-specific molecule DC-SIGN is a receptor for the HIV-1 envelope glycoprotein gp120 and is essential for the dissemination of HIV-1. DC-SIGN is expressed by DC, both monocyte-derived DC and DC in several tissues, including mucosa and lymph nodes. To identify a DC-SIGN+ DC in blood that may be involved in HIV-1 infection through blood, we have analyzed the expression of DC-SIGN on human blood cells. Here, we describe the characterization of a subset of DC in human blood, isolated from T-/NK-/B-cell depleted PBMC based on the expression of DC-SIGN. This subset co-expresses CD14, CD16 and CD33 and are thus of myeloid origin. In contrast to CD14+ monocytes, DC-SIGN+ blood cells display a DC-like morphology and express markers of antigen presenting cells, including CD1c, CD11b, CD11c, CD86 and high levels of MHC class I and II molecules. This DC population differs from other described CD14- blood DC subsets. Functionally, DC-SIGN+ blood DC are able to stimulate proliferation of allogeneic T cells and can produce TNF-[[aalpha]] and IL-6 upon activation with LPS. When encountering HIV-1 low amounts of these blood DC-SIGN+ DC enhance infection of T lymphocytes in trans, whereas blood monocytes and CD14- blood DC are not capable to transmit HIV-1. Therefore DC-SIGN+ blood DC can be the first target for HIV-1 upon transmission via blood that can capture minute amounts of HIV-1 through DC-SIGN and transfer HIV-1 to infect target T cells in trans. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? 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