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Prepublished online as a Blood First Edition Paper on September 19, 2002September 19, 2002; DOI 10.1182/blood-2001-12-0190. This Article Full Text (PDF) All Versions of this Article: 2001-12-0190v1 2001-12-0190v2 101/3/921    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Norman, K. E Articles by Hellewell, P. G Search for Related Content PubMed PubMed Citation Articles by Norman, K. E Articles by Hellewell, P. G Social Bookmarking                   What's this? Submitted December 10, 2001 Accepted September 6, 2002 Combined anti-coagulant and anti-selectin treatments prevent lethal intravascular coagulation Keith E Norman*, Matthew J Cotter, James B Stewart, Kate B Abbitt, Majid Ali, Bart E Wagner, William A Wallace, S B Forlow, and Paul G Hellewell Cardiovascular Research Group, Division of Clinical Sciences North, University of Sheffield, Sheffield, South Yorkshire, United Kingdom Department of Histopathology, Northern General Hospital, Sheffield, South Yorkshire, United Kingdom Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA * Corresponding author; email: k.norman{at}shef.ac.uk. Widespread microvascular injury followed by vessel obstruction may lead to disseminated intravascular coagulation. We describe a murine model wherein leukocytes interacting with inflamed microvessels in vivo are activated by antibodies. Treatment of TNF-primed mice with anti-Ly-6G antibodies reproduced many of the features of septic or traumatic shock including microvessel obstruction and coagulation, severe vasculitis, respiratory difficulties and vascular leakage. Mice lacking either E- or P-selectin were protected from this reaction as were animals treated with a combination of either selectin blocking antibodies and heparin or a selectin antagonist plus heparin. Combined blockade of leukocyte/platelet adhesion and coagulation may provide convincing protection in disseminated intravascular coagulation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: K. B. Abbitt, M. J. Cotter, V. C. Ridger, D. C. Crossman, P. G. Hellewell, and K. E. Norman Antibody ligation of murine Ly-6G induces neutropenia, blood flow cessation, and death via complement-dependent and independent mechanisms J. Leukoc. Biol., January 1, 2009; 85(1): 55 - 63. [Abstract] [Full Text] [PDF] G. Hutas, E. Bajnok, I. Gal, A. Finnegan, T. T. Glant, and K. Mikecz CD44-specific antibody treatment and CD44 deficiency exert distinct effects on leukocyte recruitment in experimental arthritis Blood, December 15, 2008; 112(13): 4999 - 5006. [Abstract] [Full Text] [PDF] Y. Nechemia-Arbely, D. Barkan, G. Pizov, A. Shriki, S. Rose-John, E. Galun, and J. H. Axelrod IL-6/IL-6R Axis Plays a Critical Role in Acute Kidney Injury J. Am. Soc. Nephrol., June 1, 2008; 19(6): 1106 - 1115. [Full Text] [PDF] G. J. Oostingh, M. Pozgajova, R. J. Ludwig, T. Krahn, W.-H. Boehncke, B. Nieswandt, and M. P. Schon Diminished thrombus formation and alleviation of myocardial infarction and reperfusion injury through antibody- or small-molecule-mediated inhibition of selectin-dependent platelet functions Haematologica, April 1, 2007; 92(4): 502 - 512. [Abstract] [Full Text] [PDF] D. A. Di Giusto and G. C. King Construction, Stability, and Activity of Multivalent Circular Anticoagulant Aptamers J. Biol. Chem., November 5, 2004; 279(45): 46483 - 46489. [Abstract] [Full Text] [PDF]

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