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Prepublished online as a Blood First Edition Paper on April 17, 2002; DOI 10.1182/blood-2001-12-0229. This Article Full Text (PDF) All Versions of this Article: 2001-12-0229v1 99/10/3692    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Girvin, A. M Articles by Miller, S. D Search for Related Content PubMed PubMed Citation Articles by Girvin, A. M Articles by Miller, S. D Social Bookmarking                   What's this? Submitted December 13, 2001 Accepted January 2, 2002 Differential abilities of central nervous system-resident endothelial cells and astrocytes to serve as inducible APCs Ann M Girvin, Kenneth B Gordon, C. Jane Welsh, Neil A Clipstone, and Stephen D Miller* Microbiology-Immunology, Northwestern University Medical School, Chicago, IL, USA Dermatology, Northwestern University Medical School, Chicago, IL, USA Veterinary Anatomy & Public Health, Texas A&M University, College Station, TX, USA * Corresponding author; email: s-d-miller{at}northwestern.edu. Microglial cells and astrocytes are capable of processing and presenting antigens for efficient activation of T cells. However, the antigen presenting function and role of cerebrovascular endothelial cells (CVEs) in CNS inflammatory responses remains controversial. We compared the expression of necessary accessory molecules and the functional antigen presenting capacity of cloned SJL/J CVEs and primary astrocytes in response to the pro-inflammatory cytokines IFN- and/or TNF-. Both astrocytes and CVEs upregulated MHC class II and primarily B7-1 as opposed to B7-2, in response to IFN-. TNF- inhibited the IFN- induced upregulation of MHC class II on CVEs correlating to a decrease in the mRNA for the class II transactivator (CIITA), whereas CIITA expression in astrocytes was unaffected. Unlike astrocytes, CVEs did not elicit significant MHC class II-restricted T cell responses. Furthermore, we have found that CVE monolayers are altered following T cell contact, implicating CVE/T cell contact in the breakdown of the blood brain barrier (BBB) during neuroinflammatory responses. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. R. Voskuhl, R. S. Peterson, B. Song, Y. Ao, L. B. J. Morales, S. Tiwari-Woodruff, and M. V. Sofroniew Reactive Astrocytes Form Scar-Like Perivascular Barriers to Leukocytes during Adaptive Immune Inflammation of the CNS J. Neurosci., September 16, 2009; 29(37): 11511 - 11522. [Abstract] [Full Text] [PDF] H. Shirota, L. Petrenko, C. Hong, and D. M. Klinman Potential of Transfected Muscle Cells to Contribute to DNA Vaccine Immunogenicity J. Immunol., July 1, 2007; 179(1): 329 - 336. [Abstract] [Full Text] [PDF] D. Carroll-Anzinger, A. Kumar, V. Adarichev, F. Kashanchi, and L. Al-Harthi Human Immunodeficiency Virus-Restricted Replication in Astrocytes and the Ability of Gamma Interferon To Modulate This Restriction Are Regulated by a Downstream Effector of the Wnt Signaling Pathway J. Virol., June 1, 2007; 81(11): 5864 - 5871. [Abstract] [Full Text] [PDF] I. Teige, Y. Liu, and S. Issazadeh-Navikas IFN-beta Inhibits T Cell Activation Capacity of Central Nervous System APCs J. Immunol., September 15, 2006; 177(6): 3542 - 3553. [Abstract] [Full Text] [PDF] H. Shao, S. Lei, S. L. Sun, H. J. Kaplan, and D. Sun Conversion of Monophasic to Recurrent Autoimmune Disease by Autoreactive T Cell Subsets J. Immunol., November 15, 2003; 171(10): 5624 - 5630. [Abstract] [Full Text] [PDF] J. P. Palma, D. Kwon, N. A. Clipstone, and B. S. Kim Infection with Theiler's Murine Encephalomyelitis Virus Directly Induces Proinflammatory Cytokines in Primary Astrocytes via NF-{kappa}B Activation: Potential Role for the Initiation of Demyelinating Disease J. Virol., June 1, 2003; 77(11): 6322 - 6331. [Abstract] [Full Text] [PDF] M. A. Poussin, E. Tuzun, E. Goluszko, B. G. Scott, H. Yang, J. U. Franco, and P. Christadoss B7-1 Costimulatory Molecule Is Critical for the Development of Experimental Autoimmune Myasthenia Gravis J. Immunol., April 15, 2003; 170(8): 4389 - 4396. [Abstract] [Full Text] [PDF] R. L. Reinhardt, D. C. Bullard, C. T. Weaver, and M. K. Jenkins Preferential Accumulation of Antigen-specific Effector CD4 T Cells at an Antigen Injection Site Involves CD62E-dependent Migration but Not Local Proliferation J. Exp. Med., March 17, 2003; 197(6): 751 - 762. [Abstract] [Full Text] [PDF]

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