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Prepublished online as a Blood First Edition Paper on April 17, 2002; DOI 10.1182/blood-2002-01-0011. This Article Full Text (PDF) All Versions of this Article: 2002-01-0011v1 100/2/415    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Flowers, M. E Articles by Martin, P. J Search for Related Content PubMed PubMed Citation Articles by Flowers, M. E Articles by Martin, P. J Social Bookmarking                   What's this? Submitted January 2, 2002 Accepted March 11, 2002 Comparison of chronic graft-versus-host disease after transplantation of peripheral blood stem cells versus bone marrow in allogeneic recipients: long term follow up of a randomized trial Mary E Flowers*, Pablo M Parker, Laura J Johnston, Alice V Matos, Barry Storer, William I Bensinger, Rainer Storb, Frederick R Appelbaum, Stephen J Forman, Karl G Blume, and Paul J Martin Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA City of Hope Medical Center, USA Stanford University Hospital, Stanford, CA, USA * Corresponding author; email: mflowers{at}fhcrc.org. In a previous multi-center phase III trial comparing peripheral blood stem cell transplantation (PBSCT) to bone marrow transplantation (BMT) from HLA-matched related donors, we found no statistically significant difference in the cumulative incidence of clinical extensive chronic GVHD in the 2 groups. We have analyzed the results in more detail to determine whether the clinical characteristics of chronic GVHD after PBSCT might be distinct from those that occur after BMT. Clinical extensive chronic GVHD developed in 39 of 63 PBSCT recipients and in 32 of 63 BMT recipients who were alive and free of malignancy at day 100 after the transplant. No significant differences were found in the time and type of onset of clinical extensive chronic GVHD, or in the frequency of complications associated with severe morbidity. Involvement of skin and female genital tract was more frequent in PBSCT recipients than in BMT recipients. The cumulative incidence of chronic GVHD at 3 years was similar in the 2 groups, but the number of successive treatments needed to control chronic GVHD was higher after PBSCT than after BMT (P = .03), and the duration of glucocorticoid treatment was longer after PBSCT compared to BMT (P = .03). These results suggest that chronic GVHD after PBSCT may be more protracted and less responsive to current treatment than chronic GVHD after BMT. Assessment of the overall benefits of PBSCT compared to BMT will require continued long-term follow up of morbidity associated with chronic GVHD. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. M. Imanguli, W. D. Swaim, S. C. League, R. E. Gress, S. Z. Pavletic, and F. T. Hakim Increased T-bet+ cytotoxic effectors and type I interferon-mediated processes in chronic graft-versus-host disease of the oral mucosa Blood, April 9, 2009; 113(15): 3620 - 3630. [Abstract] [Full Text] [PDF] J. L. Gajewski, V. V. Johnson, S. G. Sandler, A. Sayegh, and T. R. Klumpp A review of transfusion practice before, during, and after hematopoietic progenitor cell transplantation Blood, October 15, 2008; 112(8): 3036 - 3047. [Abstract] [Full Text] [PDF] M. E. D. Flowers, J. F. 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