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Prepublished online as a Blood First Edition Paper on May 13, 2002; DOI 10.1182/blood-2002-01-0015. This Article Full Text (PDF) All Versions of this Article: 2002-01-0015v1 100/5/1919    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Deng, H. Articles by Sun, R. Search for Related Content PubMed PubMed Citation Articles by Deng, H. Articles by Sun, R. Social Bookmarking                   What's this? Submitted January 4, 2002 Accepted April 19, 2002 Rta of human herpesvirus 8/Kaposi's sarcoma-associated herpesvirus up-regulates human interleukin-6 gene expression Hongyu Deng, Julia T Chu, Matthew B Rettig, Otoniel Martinez-Maza, and Ren Sun* Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, California, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California, USA Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, California, USA Medicine (West LA VAMC), University of California, Los Angeles, Los Angeles, California, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California, USA Obstetrics and Gynecology, Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, California, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California, USA Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, California, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California, USA; AIDS Institute, Molecular Biology Institute, Dental Research Institute, University of California, Los Angeles, Los Angeles, California, USA * Corresponding author; email: rsun{at}mednet.ucla.edu. Human herpesvirus 8 (HHV-8)/Kaposi's sarcoma-associated herpesvirus (KSHV) is linked to a number of malignancies that are thought to be driven by cytokines including interleukin-6 (IL-6). Rta, a transcriptional activator encoded by HHV-8/KSHV, activates the viral lytic cycle leading to expression of several viral genes that are implicated in viral pathogenesis. However, the effect of HHV-8/KSHV Rta on cellular genes has not been reported. We present evidence that the human IL-6 (hIL-6) gene is up-regulated by Rta. Rta potently activated (up to 164-fold) the hIL-6 promoter in a dose-dependent manner in a transient transfection reporter system. Rta also induced expression of the endogenous hIL-6 gene, as shown by enzyme-linked immunosorbent assays. Activation of the hIL-6 gene by HHV-8/KSHV supports the role of hIL-6 in the development of these malignancies. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? 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