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Prepublished online as a Blood First Edition Paper on May 13, 2002; DOI 10.1182/blood-2002-01-0110. This Article Full Text (PDF) All Versions of this Article: 2002-01-0110v1 99/12/4379    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hoelzer, D. Articles by Walewski, J. Search for Related Content PubMed PubMed Citation Articles by Hoelzer, D. Articles by Walewski, J. Social Bookmarking                   What's this? Submitted January 15, 2002 Accepted February 20, 2002 Outcome of adult patients with T-lymphoblastic lymphoma treated according to protocols for acute lymphoblastic leukemia (ALL) Dieter Hoelzer*, Nicola Goekbuget, Werner Digel, Thomas Faak, Michael Kneba, Regina Reutzel, Joanna Romejko-Jarosinska, Jacek Zwolinski, and Jan Walewski Department of Hematology, University of Frankfurt, Frankfurt, Germany Department of Hematology, University of Freiburg, Freiburg, Germany Deparment of Hematology, General Hospital St. Georg, Hamburg, Germany Department of Lymphoma, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland * Corresponding author; email: hoelzer{at}em.uni-frankfurt.de. 45 adult patients with T-lymphoblastic lymphoma (T-LBL) (15-61 years) were treated with two protocols designed for adult ALL. An encouraging cure rate of 90% was recently reported for T-LBL in children treated with a similar approach. In our study a 8-drug standard induction was administered over 8 weeks including prophylactic cranial (24 Gy) and mediastinal irradiation (24 Gy) followed by consolidation and reinduction therapy. At diagnosis 91% of the 45 patients showed a mediastinal tumor and 40% had pleural/pericardial effusions. 73% of the patients had stage III/IV disease. Overall 42 patients (93%) achieved a complete remission (CR), 2 patients (4%) a partial remission and 1 patient (2%) died during induction. In patients with stage I-III disease (N=18) the CR rate was 100% compared to 89% in stage IV (N=27). 15 patients relapsed (36%) all of them within 12 months. The majority of relapses (47%) occurred in the mediastinum (N=7) despite mediastinal irradiation with 24 Gy in 6/7 patients. The estimates for overall survival, continuous CR and disease free survival at 7 years are 51%, 65% and 62% respectively. Stage, age, LDH and all other parameters had no influence on achievement of CR or outcome. This study demonstrates in a large cohort of adult T-LBL that a high CR rate and a favourable outcome can be achieved with an ALL-type regimen. Mediastinal recurrence was the major obstacle and further improvement by intensification of chemotherapy, increased dose of mediastinal irradiation (36 Gy) and extended indications for SCT seems to be required. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: B. Burkhardt, A. Reiter, E. Landmann, P. Lang, L. Lassay, R. Dickerhoff, M. Lakomek, G. Henze, and A. von Stackelberg Poor Outcome for Children and Adolescents With Progressive Disease or Relapse of Lymphoblastic Lymphoma: A Report From the Berlin-Frankfurt-Muenster Group J. Clin. Oncol., July 10, 2009; 27(20): 3363 - 3369. [Abstract] [Full Text] [PDF] F. Baleydier, A.-V. Decouvelaere, J. Bergeron, P. Gaulard, D. Canioni, Y. Bertrand, S. Lepretre, B. Petit, H. Dombret, K. Beldjord, et al. 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