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Prepublished online as a Blood First Edition Paper on April 17, 2002; DOI 10.1182/blood-2002-01-0144.
Submitted January 16, 2002
Accepted February 23, 2002
Non-disjunction of chromosomes leading to hyperdiploid childhood B cell precursor acute lymphoblastic leukemia is an early event during leukemogenesis
E. Renate Panzer-Grumayer*, Karin Fasching, Simon Panzer, Klaudia Hettinger, Klaus Schmitt, Sylvia Stockler-Ipsiroglu, and Oskar A Haas
St. Anna Kinderspital, Children's Cancer Research Institute, Vienna, Austria; St. Anna Kinderspital, Vienna, Austria
St. Anna Kinderspital, Children's Cancer Research Institute, Vienna, Austria
University of Vienna, Clinic for Blood Group Serology, Vienna, Austria
Landeskinderkrankenhaus Linz, Linz, Austria
Department of Pediatrics, University of Vienna, Austrian Newborn Screening Laboratory, Vienna, Austria
* Corresponding author; email: panzer{at}ccri.univie.ac.at.
A hyperdiploid karyotype is found in 30% of B cell precursor acute lymphoblastic leukemias (ALL) in childhood. The time of non-disjunction of chromosomes leading to hyperdiploidy during leukemogenesis is unknown. We used the three clonotypic immunoglobulin heavy chain (IgH) gene rearrangements as molecular markers for each of the three chromosome 14 in a hyperdiploid ALL to define the order of events, namely somatic recombination and non-disjunction of chromosomes, during leukemia development. A partial sequence homology of the incomplete DJH rearrangement with one of the two non-functional VDJH rearrangements suggests that the doubling of chromosomes had occurred after this DJH rearrangement, thus during early B cell differentiation. In this case the occurrence of the non-disjunction of chromosomes as well as ongoing rearrangement processes in utero were confirmed by the presence of all three IgH rearrangements in neonatal blood spots, providing first evidence that hyperdiploidy formation is an early event in leukemogenesis in these leukemias.
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