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Prepublished online as a Blood First Edition Paper on May 13, 2002; DOI 10.1182/blood-2002-01-0151.
Submitted January 17, 2002
Accepted April 25, 2002
Bay 11-7082 inhibits transcription factor NF- B and induces apoptosis of HTLV-I infected T-cell lines and primary adult T-cell leukemia cells
Naoki Mori*, Yasuaki Yamada, Shuichi Ikeda, Yoshihiro Yamasaki, Kunihiro Tsukasaki, Yuetsu Tanaka, Masao Tomonaga, Naoki Yamamoto, and Masahiro Fujii
Department of Preventive Medicine and AIDS Research, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan
Department of Laboratory Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
Department of Internal Medicine, Sasebo City General Hospital, Sasebo, Japan
Department of Internal Medicine, Kokura Memorial Hospital, Kitakyushu, Japan
Department of Hematology, Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Nagasaki, Japan
Department of Infectious Disease and Immunology, Okinawa-Asia Research Center of Medical Science, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
Division of Virology, Niigata University Graduate School of Medicine and Dental Sciences, Niigata, Japan
* Corresponding author; email: n-mori{at}med.u-ryukyu.ac.jp.
Human T-cell leukemia virus type I (HTLV-I) is the causative agent of an aggressive form of leukemia designated as adult T-cell leukemia (ATL). We have previously demonstrated that all T-cell lines infected with HTLV-I and primary leukemic cells from ATL patients display constitutively high activity of transcription factor NF-B. Here we showed that Bay 11-7082, an inhibitor of NF-B, induced apoptosis of HTLV-I infected T-cell lines, but only negligible apoptosis of HTLV-I negative T cells. Bay 11-7082 rapidly and efficiently reduced the DNA binding of NF-B in HTLV-I infected T-cell lines, and down-regulated the expression of the antiapoptotic gene, Bcl-xL, regulated by NF-B, while it little affected the DNA binding of another transcription factor AP-1. Although the viral protein Tax is an activator of NF-B, Bay 11-7082-induced apoptosis of HTLV-I infected cells was not associated with reduced expression of Tax. Furthermore, Bay 11-7082-induced apoptosis of primary ATL cells was more prominent than that of normal peripheral blood mononuclear cells, and apoptosis of these cells was also associated with down-regulation of NF-B activity. Our results indicate that NF-B plays a crucial role in the pathogenesis and survival of HTLV-I infected leukemic cells, and that it is a suitable target for the prevention and treatment of ATL.
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M. Brown, M. Bellon, and C. Nicot
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109(4):
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|
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|
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|
|
|
|
|
|
|
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|
|
|
|
|
|
|
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107(12):
4880 - 4887.
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|
|
|
|
|
|
|
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107(11):
4491 - 4499.
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|
|
|
|
|
|
|
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5(3):
704 - 712.
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|
|
|
|
|
|
|
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107(2):
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|
|
|
|
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M. Watanabe, T. Ohsugi, M. Shoda, T. Ishida, S. Aizawa, M. Maruyama-Nagai, A. Utsunomiya, S. Koga, Y. Yamada, S. Kamihira, et al.
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106(7):
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|
|
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|
|
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|
|
|
|
|
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|
|
|
|
|
|
|
F. Larousserie, E. Bardel, S. Pflanz, B. Arnulf, C. Lome-Maldonado, O. Hermine, L. Bregeaud, M. Perennec, N. Brousse, R. Kastelein, et al.
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166(4):
1217 - 1228.
[Abstract]
[Full Text]
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|
|
|
|
|
|
|
T. Sanda, S. Iida, H. Ogura, K. Asamitsu, T. Murata, K. B. Bacon, R. Ueda, and T. Okamoto
Growth Inhibition of Multiple Myeloma Cells by a Novel I{kappa}B Kinase Inhibitor
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11(5):
1974 - 1982.
[Abstract]
[Full Text]
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|
|
|
|
|
|
|
T. Matsuda, A. Almasan, M. Tomita, J.-n. Uchihara, M. Masuda, K. Ohshiro, N. Takasu, H. Yagita, T. Ohta, and N. Mori
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79(3):
1367 - 1378.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. R. Jazirehi, S. Huerta-Yepez, G. Cheng, and B. Bonavida
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65(1):
264 - 276.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Devadas, N. J. Hardegen, L. M. Wahl, I. K. Hewlett, K. A. Clouse, K. M. Yamada, and S. Dhawan
Mechanisms for Macrophage-Mediated HIV-1 Induction
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173(11):
6735 - 6744.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Vora, A. Youdim, L. S. Thomas, M. Fukata, S. Y. Tesfay, K. Lukasek, K. S. Michelsen, A. Wada, T. Hirayama, M. Arditi, et al.
{beta}-Defensin-2 Expression Is Regulated by TLR Signaling in Intestinal Epithelial Cells
J. Immunol.,
November 1, 2004;
173(9):
5398 - 5405.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Zhang, Z.-N. Lin, C.-F. Yang, X. Shi, C.-N. Ong, and H.-M. Shen
Suppressed NF-{kappa}B and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-{alpha}-induced apoptosis in human cancer cells
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November 1, 2004;
25(11):
2191 - 2199.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Sinha-Datta, I. Horikawa, E. Michishita, A. Datta, J. C. Sigler-Nicot, M. Brown, M. Kazanji, J. C. Barrett, and C. Nicot
Transcriptional activation of hTERT through the NF-{kappa}B pathway in HTLV-I-transformed cells
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October 15, 2004;
104(8):
2523 - 2531.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S.-J. Jeong, M. Radonovich, J. N. Brady, and C. A. Pise-Masison
HTLV-I Tax induces a novel interaction between p65/RelA and p53 that results in inhibition of p53 transcriptional activity
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104(5):
1490 - 1497.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Luft, E. Maraskovsky, M. Schnurr, K. Knebel, M. Kirsch, M. Gorner, R. Skoda, A. D. Ho, P. Nawroth, and A. Bierhaus
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104(4):
1066 - 1074.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Zhang, J. Zhu, A. Imrich, M. Cushion, T. B. Kinane, and H. Koziel
Pneumocystis Activates Human Alveolar Macrophage NF-{kappa}B Signaling through Mannose Receptors
Infect. Immun.,
June 1, 2004;
72(6):
3147 - 3160.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Mori, T. Matsuda, M. Tadano, T. Kinjo, Y. Yamada, K. Tsukasaki, S. Ikeda, Y. Yamasaki, Y. Tanaka, T. Ohta, et al.
Apoptosis Induced by the Histone Deacetylase Inhibitor FR901228 in Human T-Cell Leukemia Virus Type 1-Infected T-Cell Lines and Primary Adult T-Cell Leukemia Cells
J. Virol.,
May 1, 2004;
78(9):
4582 - 4590.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Dai, X.-Y. Pei, M. Rahmani, D. H. Conrad, P. Dent, and S. Grant
Interruption of the NF-{kappa}B pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells
Blood,
April 1, 2004;
103(7):
2761 - 2770.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Guthridge, E. F. Barry, F. A. Felquer, B. J. McClure, F. C. Stomski, H. Ramshaw, and A. F. Lopez
The phosphoserine-585-dependent pathway of the GM-CSF/IL-3/IL-5 receptors mediates hematopoietic cell survival through activation of NF-{kappa}B and induction of bcl-2
Blood,
February 1, 2004;
103(3):
820 - 827.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. E. Rusinol, D. Thewke, J. Liu, N. Freeman, S. R. Panini, and M. S. Sinensky
AKT/Protein Kinase B Regulation of BCL Family Members during Oxysterol-induced Apoptosis
J. Biol. Chem.,
January 9, 2004;
279(2):
1392 - 1399.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Mohapatra, B. Chu, S. Wei, J. Djeu, P. K. Epling-Burnette, T. Loughran, R. Jove, and W. J. Pledger
Roscovitine Inhibits STAT5 Activity and Induces Apoptosis in the Human Leukemia Virus Type 1-Transformed Cell Line MT-2
Cancer Res.,
December 1, 2003;
63(23):
8523 - 8530.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. J. Brown, M. J. Song, H. Deng, T.-T. Wu, G. Cheng, and R. Sun
NF-{kappa}B Inhibits Gammaherpesvirus Lytic Replication
J. Virol.,
August 1, 2003;
77(15):
8532 - 8540.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Mori, A. M. Krensky, R. Geleziunas, A. Wada, T. Hirayama, C. Sasakawa, and N. Yamamoto
Helicobacter pylori Induces RANTES through Activation of NF-{kappa}B
Infect. Immun.,
July 1, 2003;
71(7):
3748 - 3756.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Z. Dewan, K. Terashima, M. Taruishi, H. Hasegawa, M. Ito, Y. Tanaka, N. Mori, T. Sata, Y. Koyanagi, M. Maeda, et al.
Rapid Tumor Formation of Human T-Cell Leukemia Virus Type 1-Infected Cell Lines in Novel NOD-SCID/{gamma}cnull Mice: Suppression by an Inhibitor against NF-{kappa}B
J. Virol.,
May 1, 2003;
77(9):
5286 - 5294.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. C. Bunnell
Determining the Destiny of NF-{kappa} B after TCR Ligation: It's CARMA1
Mol. Interv.,
October 1, 2002;
2(6):
356 - 360.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
