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Prepublished online as a Blood First Edition Paper on April 17, 2002; DOI 10.1182/blood-2002-01-0209. This Article Full Text (PDF) Erratum (v100,p3483) All Versions of this Article: 2002-01-0209v1 100/2/718    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Miller, J. W Articles by Green, R. Search for Related Content PubMed PubMed Citation Articles by Miller, J. W Articles by Green, R. Related Collections Related Letter in Blood Online Social Bookmarking                   What's this? Submitted January 25, 2002 Accepted March 9, 2002 Transcobalamin II G775C Polymorphism and Indices of Vitamin B12 Status in Healthy Older Adults Joshua W Miller*, Marisa I Ramos, Marjorie G Garrod, Margaret A Flynn, and Ralph Green Medical Pathology, University of California, Davis, School of Medicine, Sacramento, CA, USA Nutrition, University of California, Davis, Davis, CA, USA Family and Community Medicine, University of Missouri, Columbia, School of Medicine, Columbia, MO, USA * Corresponding author; email: jwmiller{at}ucdavis.edu. A common polymorphism (G775C) in the vitamin B12 transport protein, transcobalamin II (TCII), has been identified in which proline replaces arginine at codon 259. We determined the influence of TCII genotype on indices of B12 status, including total serum B12, the amount of B12 bound to TCII (holoTCII), methylmalonic acid, and homocysteine, in 128 healthy older adults (age 40-88y). Mean total B12 and homocysteine concentrations were not significantly different among the three genotypes. Mean holoTCII concentration was significantly higher in those subjects homozygous for the proline form of TCII (PP) compared with those homozygous for the arginine form (RR) and heterozygotes (PR) (p0.006). In addition, mean methylmalonic acid concentrations were significantly lower in the PP and PR groups compared with the RR group (p0.02). The PP genotype may be more efficient in delivering B12 to tissues resulting in enhanced B12 functional status. TCII genotype may thus influence susceptibility to B12 deficiency. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Letter in Blood Online: The transcobalamin codon 259 polymorphism should be designated 776C>G, not 775G>C Henrik Zetterberg, Mona Palmér, Cecilia Boreström, Lars Rymo, Kaj Blennow, Joshua W. Miller, and Ralph Green Blood 2003 101: 3749-3750. 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